{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:14:48Z","timestamp":1790230488094,"version":"4.1.0"},"reference-count":64,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":32,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The research underscores an important gap in the management of chronic wounds, which frequently exhibit resistance to standard therapies. Maggot debridement therapy shows promise in removing necrotic tissue; however, data comparing its efficacy to conventional treatments is limited. We conducted a systematic review and meta\u2010analysis of randomised controlled trials to assess the effectiveness of maggot debridement therapy versus conventional therapies, including commonly used wound care interventions such as hydrogel dressings, compression therapy, vacuum\u2010assisted closure (VAC) therapy, sharp debridement, and so on. The population was defined as patients with chronic wounds, including venous leg ulcers, arterial ulcers, mixed arterial\u2013venous leg ulcers, diabetic foot ulcers, and full\u2010thickness burns. Primary outcomes assessed were the proportion of wound healing and time to wound healing, while secondary outcomes were time to wound debridement, reduction of slough, infection\u2010free rate, eradication of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    <\/jats:styled-content>\n                    , and ulcer\u2010related pain. Ten randomised controlled trials involving 839 participants were incorporated. Maggot debridement therapy markedly decreased the duration of wound debridement compared to conventional treatment (hazard ratio: 5.16,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0006) and showed a borderline significant reduction in slough during the first week (mean difference: 17.06,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.05). Maggot debridement therapy and conventional treatment did not vary in the proportion of wound healing (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.17), time to wound healing (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.14), infection\u2010free rates (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.10), eradication of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.11) and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    <\/jats:styled-content>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.46), or ulcer\u2010related pain (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.54). Maggot debridement therapy may be an effective preliminary debridement technique for wound bed preparation in chronic wounds, especially before advanced interventions such as skin grafting, and is particularly advantageous for chronic wounds unresponsive to conventional therapies. Further research is required to confirm the findings.\n                  <\/jats:p>","DOI":"10.1111\/wrr.70095","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T12:11:59Z","timestamp":1759493519000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effectiveness of Maggot Debridement Therapy for Chronic Wounds: A Systematic Review and Meta\u2010Analysis of Randomised Controlled Trials"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1903-5763","authenticated-orcid":false,"given":"Chun\u2010Jun","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Medical Education Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Wei","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Education Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szu\u2010Hsien","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Medicine National Yang Ming Chiao Tung University School of Medicine  Taipei Taiwan"},{"name":"Division of Plastic and Reconstructive Surgery Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao\u2010Min","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Medical Education Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of Medicine National Yang Ming Chiao Tung University School of Medicine  Taipei Taiwan"},{"name":"Division of Evidence\u2010Based Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Institute of Public Health and Community Medicine Research Centre National Yang Ming Chiao Tung University School of Medicine  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11020457"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000225430.42531.c2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2006.12.005"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2018.10.005"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2021.102876"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-821X(05)80313-5"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/15385744241264336"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2012.21.4.168"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.70177"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.33235\/wpr.27.4.164\u2010167"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2015.24.Sup20.S52"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2023.04.015"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2015.24.11.498"},{"issue":"2","key":"e_1_2_9_15_1","first-page":"290","article-title":"A Randomized Controlled Trial of Larval Therapy for the Debridement of Leg Ulcers: Results of a Multicenter, Randomized, Controlled, Open, Observer Blind, Parallel Group Study","volume":"22","author":"Mudge E.","year":"2014","journal-title":"Wound Repair and Regeneration"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2007.00321.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737159.2014.927312"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2018.10.011"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b773"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.1895"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(03)00307-6"},{"issue":"1","key":"e_1_2_9_22_1","first-page":"S1","article-title":"Wound Bed Preparation: A Systematic Approach to Wound Management","volume":"11","author":"Schultz G. 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