{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:56:03Z","timestamp":1788926163659,"version":"build-2803163510"},"reference-count":133,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Skin organoids are 3D multicellular systems formed through self\u2010organisation in\u00a0vitro, driving research toward functional\u2010related phenotypic replication from structural mimicry to functionally relevant phenotypic replication. However, this field still faces challenges in improving vascularisation, neurogenesis, and immune integration. This review provides a comprehensive overview of the latest advancements in this field. First, it organises the construction of epidermis\u2013dermis\u2013basement membrane units, vascular\/neural\/immune modules and accessory organs such as hair follicles, sweat glands, and sebaceous glands into \u2018component\u2014source\u2014function readout\u2019 to highlight key points and clinically relevant endpoints (barrier function, hair growth, sweat gland secretion, and sensation). Subsequently, it outlines the key culture and assembly elements (extracellular matrix composition and mechanics, air\u2013liquid interface, perfusion\/organ\u2010on\u2010a\u2010chip and bioprinting) that influence the maturation trajectory of tissues. Then, it compares the differences in plasticity, maturity and accessibility between pluripotent stem cells, adult\/primary cells and patient\u2010derived cells. At the application level, it concludes that skin organoids have been used to model inflammation, genetic disorders, infections, and tumours, enabling simultaneous efficacy and safety readouts in drug discovery and toxicology assessment. Translation challenges include vascularisation and perfusion, neurogenesis and sensory function, immune integration, batch consistency and GMP quality, scalability and cost. We propose a staged validation pathway integrating engineering, biology and regulatory considerations, and envision optimisations combining multi\u2010omics, chemoproteomics and artificial intelligence to accelerate the transition from research\u2010grade prototypes to clinical applications.<\/jats:p>","DOI":"10.1111\/wrr.70117","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T12:55:38Z","timestamp":1767358538000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Skin Organoids for Disease Modelling, Drug Screening and Regenerative Medicine: Recent Advances and Future Perspectives"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7727-4523","authenticated-orcid":false,"given":"Dan","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Drug Discovery Technology, Ningbo University  Ningbo China"},{"name":"Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Ningbo University  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manzoor","family":"Majid","sequence":"additional","affiliation":[{"name":"Institute of Drug Discovery Technology, Ningbo University  Ningbo China"},{"name":"Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Ningbo University  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiani","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Drug Discovery Technology, Ningbo University  Ningbo China"},{"name":"Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Ningbo University  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjie","family":"Wu","sequence":"additional","affiliation":[{"name":"Innovative Institute of Chinese Medicine and Pharmacy\/Academy for Interdisciplinary, Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzong","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Drug Discovery Technology, Ningbo University  Ningbo China"},{"name":"Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Ningbo University  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Ni","sequence":"additional","affiliation":[{"name":"Institute of Drug Discovery Technology, Ningbo University  Ningbo China"},{"name":"Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Ningbo University  Ningbo China"},{"name":"LeadArt Biotechnologies Ltd.  Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a023267"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12832"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586\u2010018\u201007428\u20104"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/026119291003800309"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202201626"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.709824"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523\u20101747.ep12722530"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0092\u20108674(75)80001\u20108"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201709054"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010020\u20102352\u20103"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25052680"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.105150"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40779\u2010023\u201000475\u20107"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkae077"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/procel\/pwae055"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14292"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12914"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00110"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010022\u201005525\u2010x"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14823"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.3791\/59297"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010018\u20100958\u20102"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2020.06.039"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2022.04.008"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010021\u201002910\u20108"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm\u201022\u20103252"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201031842\u2010y"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.add4603"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep26436"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/03009858231176561"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201010261\u20106"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202103079"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12773"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010019\u20101485\u20105"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.09.019"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2023.102334"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201500936"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202500301"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201033114\u20101"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010024\u201007226\u2010x"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523\u20101747.ep12471760"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13891"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.7"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42777"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkae070"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201008002\u2010x"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2019.111627"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202304879"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.97422"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2100749118"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkae003"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105\u2010019\u201004537\u20107"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.2953"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23282"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.83217"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202400405"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14071417"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4lc00437j"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.201900170"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2013.0547"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11132093"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2020.0263"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14020319"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4538"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13010055"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202104192"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202106075"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201004727\u20109"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41522\u2010020\u201000182\u20104"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26853"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.59661"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.12.007"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010020\u201003330\u2010y"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2023.03.002"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010019\u20101504\u20106"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14243"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020107135"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.024"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010019\u20101212\u20102"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2022.04.009"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(09)61496\u20103"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1177\/09636897231156215"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.07.009"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010022\u201002918\u20109"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2022.2144667"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6544514"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010022\u201001728\u20108"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010022\u201002980\u20103"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24108688"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.s377317"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.2c00902"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13577\u2010023\u201000904\u20108"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010022\u201003082\u2010w"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2022.12.006"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15022"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10354"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010022\u201001503\u20109"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2023.03.017"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.22203\/ecm.v037a14"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40779\u2010023\u201000472\u2010w"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052410"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.122.001412"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.13116"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.09.120"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010022\u201001504\u20108"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/wdev.307"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.2337\/db21\u20100724"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2021.1894813"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201023304\u20108"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15028"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010018\u20100003\u20100"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13010138"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201031502\u20106"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2023.06.005"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc\u20102021\u2010002432"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12887"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326\u20106066.cir\u201015\u20100096"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201057610\u20102"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology13080555"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010020\u20100186\u2010y"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adk5864"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.70019"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57040348"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05664"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.01.025"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2019.0319"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adf7547"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010023\u201005057\u20103"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.126010"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.1039117"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.08.036"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2025.214487"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.09.005"}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.70117","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/wrr.70117","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.70117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:33:27Z","timestamp":1772969607000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.70117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":133,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/wrr.70117"],"URL":"https:\/\/doi.org\/10.1111\/wrr.70117","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-09-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70117"}}