{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:40:57Z","timestamp":1775742057426,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Approximately 20% of chronic leg ulcers remain recalcitrant despite treatment of underlying factors and best standard of wound care. This study aimed to evaluate the effectiveness of partial\u2010thickness punch grafting in promoting healing and reducing pain in patients with chronic, hard\u2010to\u2010heal leg ulcers of various causes. In this single\u2010centre, retrospective cohort study, 93 patients were treated between January 2016 and December 2024, with follow\u2010up at 1, 3, 6 and 12\u2009months. The primary outcome was complete wound healing, while secondary outcomes included pain reduction and wound surface changes. At 12\u2009months, 78\/88 analysed patients (88.6%) achieved complete healing of the target ulcer. Pain levels improved substantially, with the proportion of pain\u2010free patients increasing from 17.6% at baseline to 76.3% at 6\u2009months. Donor site complications were minimal (6.5%) and cosmetic outcomes were excellent. Recurrence after 12\u2010month follow\u2010up occurred in only 9% of healed ulcers within 12\u2009months. These results confirm that partial\u2010thickness punch grafting is a highly effective and minimally invasive technique for treating hard\u2010to\u2010heal leg ulcers, delivering durable healing, rapid pain relief and low morbidity. This study provides new long\u2010term data supporting the broad clinical utility of punch grafting across diverse ulcer types.<\/jats:p>","DOI":"10.1111\/wrr.70126","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T07:55:48Z","timestamp":1768377348000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness of Punch Grafting in Promoting Healing and Reducing Pain in Hard\u2010to\u2010Heal Leg Ulcers"],"prefix":"10.1111","volume":"34","author":[{"given":"Julia","family":"Neuenschwander","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter O.","family":"Mayer","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramon","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Staub\u2010Buset","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirjam","family":"N\u00e4geli","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrg","family":"Hafner","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnsa.2025.100313"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643\u2010016\u20100400\u20108"},{"issue":"1","key":"e_1_2_12_4_1","first-page":"6","article-title":"Chronic Wounds: A Rising Public Health Concern","volume":"7","author":"Maheshwari G.","year":"2024","journal-title":"Wounds APAC"},{"issue":"1","key":"e_1_2_12_5_1","first-page":"8","article-title":"Chronic Wounds: Magnitude, Socioeconomic Burden and Consequences","volume":"4","author":"Maheshwari G.","year":"2021","journal-title":"Wounds Asia"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2009.18.4.41607"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2023.0150"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/15347346241246339"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2014.23.12.601"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1024\/0040\u20105930\/a001032"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000265.pub3"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2021.04.006"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524\u2010475X.2009.00543.x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14709"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2019.28.Sup3a.S1"},{"issue":"3","key":"e_1_2_12_16_1","first-page":"159","article-title":"Chronic Wounds: Evaluation and Management","volume":"101","author":"Bowers S.","year":"2020","journal-title":"American Family Physician"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12994"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000733724.87630.d6"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/ASW.0000000000000120"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129334\u2010200401000\u201000012"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v8.i21.5070"},{"issue":"2","key":"e_1_2_12_22_1","first-page":"E9","article-title":"Martorell Hypertensive Ischemic Ulcer Successfully Treated With Punch Skin Grafting","volume":"30","author":"Conde Montero E.","year":"2018","journal-title":"Wounds"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmv.2016.08.002"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcws.2012.03.001"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000003891"},{"key":"e_1_2_12_26_1","first-page":"511","article-title":"Greffe \u00e9pidermique. 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