{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T04:12:07Z","timestamp":1774066327313,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:00:00Z","timestamp":1770336000000},"content-version":"vor","delay-in-days":36,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100020070","name":"Wound Management Innovation Cooperative Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic venous disease underlies the pathogenicity of venous leg ulcers. However, it is unknown why some people with chronic venous disease are more susceptible to the development of venous leg ulcers (VLUs) than others. While there is evidence of a genetic component, our understanding of how specific genetic variants influence the development of chronic wounds and more specifically (VLUs) is limited. The aim of this study was to determine if specific genetic variants associated with the iron overload disorder haemochromatosis,\n                    <jats:italic>HFE<\/jats:italic>\n                    p.C282Y and\n                    <jats:italic>HFE<\/jats:italic>\n                    p.H63D, predispose to the development of VLUs. A total of 78 individuals with VLUs were genotyped for\n                    <jats:italic>HFE<\/jats:italic>\n                    variants and results compared to the\n                    <jats:italic>HFE<\/jats:italic>\n                    variant and genotype frequencies found in three different Australian population\u2010based studies. The allele frequency of the\n                    <jats:italic>HFE<\/jats:italic>\n                    p.C282Y variant was 12.8% among individuals with a VLU, significantly higher than the frequencies of this variant reported in the three Australian population\u2010based studies. The combined frequency of all genotypes containing the p.C282Y variant (HH\/CY, HD\/CY and HH\/YY) was also significantly higher among individuals with a VLU compared to the control populations. The analysis of Australian individuals with VLUs indicates that the\n                    <jats:italic>HFE<\/jats:italic>\n                    p.C282Y variant is a genetic risk factor for the development of VLUs, suggesting that altered iron regulation may be a contributing factor to VLU pathogenesis.\n                  <\/jats:p>","DOI":"10.1111\/wrr.70127","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T10:45:15Z","timestamp":1770374715000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An Association Between Haemochromatosis Genotypes and Venous Leg Ulcers in Australian Individuals"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3834-205X","authenticated-orcid":false,"given":"Christina N.","family":"Parker","sequence":"first","affiliation":[{"name":"School of Nursing, Faculty of Health, Queensland University of Technology  Brisbane Australia"},{"name":"Centre for Healthcare Transformation, Faculty of Health, Queensland University of Technology  Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Maresco\u2010Pennisi","sequence":"additional","affiliation":[{"name":"School of Nursing, Faculty of Health, Queensland University of Technology  Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5743-2731","authenticated-orcid":false,"given":"Kathleen","family":"Finlayson","sequence":"additional","affiliation":[{"name":"School of Nursing, Faculty of Health, Queensland University of Technology  Brisbane Australia"},{"name":"Centre for Healthcare Transformation, Faculty of Health, Queensland University of Technology  Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Sydes","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Faculty of Health, Queensland University of Technology  Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Kaim","sequence":"additional","affiliation":[{"name":"St Vincent's Private Hospital  Toowoomba Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel A.","family":"Broszczak","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Faculty of Health, Queensland University of Technology  Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7827-5344","authenticated-orcid":false,"given":"Emma","family":"Hall","sequence":"additional","affiliation":[{"name":"School of Nursing, Faculty of Health, Queensland University of Technology  Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha","family":"Pitman","sequence":"additional","affiliation":[{"name":"School of Nursing, Faculty of Health, Queensland University of Technology  Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony J.","family":"Parker","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Faculty of Health, Queensland University of Technology  Brisbane Australia"},{"name":"Centre for Biomedical Technologies, Queensland University of Technology  Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice L.","family":"Atkins","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biomedical Sciences Faculty of Health and Life Sciences, University of Exeter  Exeter UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel F.","family":"Wallace","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Faculty of Health, Queensland University of Technology  Brisbane Australia"},{"name":"Centre for Genomics and Personalised Health, Queensland University of Technology  Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"e_1_2_13_2_1","volume-title":"Best Practice Recommendations For Skin Health and Wound Management","author":"Evans R.","year":"2025"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/413604"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvn.2015.01.003"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2008.12.012"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.33235\/wpr.31.1.7\u201018"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14272"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/WON.0000000000000622"},{"key":"e_1_2_13_9_1","unstructured":"L.LizarondoandS.Bellman \u201cVenous Leg Ulcer: Compression Therapy \u201dThe JBI EBPDatabase vol. JBI\u2010ES\u20104169\u20107 2023 [Online] http:\/\/ovidsp.ovid.com\/ovidweb.cgi?T=JS&PAGE=reference&D=jbi&NEWS=N&AN=JBI119346."},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2019.28.2.59"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr_00000241"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep45652"},{"key":"e_1_2_13_13_1","volume-title":"Genetic Variation of Teh HFE Gene and Associated Proteomes in Chronic Venous Leg Ulceration [Unpublished Degree Type Thesis or Dissertation]","author":"Sydes E.","year":"2019"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/ASW.0000000000000080"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00156"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073286"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22972"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.34.4.275"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2006.01.026"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2005.04.003"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1086\/302862"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909023411002"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2010.08.015"},{"issue":"2","key":"e_1_2_13_24_1","first-page":"51","article-title":"The Regulation of Iron Absorption and Homeostasis","volume":"37","author":"Wallace D. F.","year":"2016","journal-title":"Clinical Biochemist Reviews"}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.70127","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/wrr.70127","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.70127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:33:30Z","timestamp":1772969610000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.70127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/wrr.70127"],"URL":"https:\/\/doi.org\/10.1111\/wrr.70127","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-11-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70127"}}