{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:34:30Z","timestamp":1779298470455,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":42,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Diabetes\u2010related lower extremity amputations (LEAs) are a significant global issue, exacerbated by the rising prevalence of diabetes and peripheral artery disease (PAD). Traditional revascularization techniques often fail in patients with severe vascular damage or comorbidities. Tibial Osteodistraction angiogenesis (ODA) represents a novel approach, leveraging angiogenesis to improve perfusion and wound healing. A systematic review was conducted across four databases. Inclusion criteria focused on studies evaluating ODA in diabetic foot ulcers and chronic ischemic wounds. Outcomes analysed included amputation rates, wound healing, mortality, and safety metrics. Eighteen studies (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20093000 treated with ODA) were included, with subjects aged 35\u201387. Diabetes prevalence was 87.8%. ODA demonstrated high limb salvage rates (92%\u2013100%) and wound healing rates (58%\u2013100%). Pooled analysis revealed amputation rates of 2% and mortality rates of 4%. Angiogenic cytokine levels increased post\u2010procedure, suggesting enhanced angiogenesis. Complications were minimal, with a 3% pin\u2010site infection rate and 4% major adverse limb events. ODA offers a promising addition for patients with limb\u2010threatening ischemia, achieving significant improvements in perfusion, wound healing, and limb salvage. Despite study heterogeneity and limitations, ODA's angiogenic benefits warrant further research through randomised clinical trials to validate its efficacy and broaden clinical adoption.\n                  <\/jats:p>","DOI":"10.1111\/wrr.70130","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T09:28:33Z","timestamp":1770888513000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Tibial Osteodistraction Angiogenesis for Diabetic Foot Ischemia: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5311-6283","authenticated-orcid":false,"given":"Arthur","family":"Tarricone","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery University of Texas Health Science Center  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen","family":"Gee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Mount Sinai Morningside Hospital  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee C.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery University of Texas Health Science Center  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Lavery","sequence":"additional","affiliation":[{"name":"Statistic Consulting  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael C.","family":"Siah","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2871-3689","authenticated-orcid":false,"given":"Prakash","family":"Krishnan","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. Wiener Cardiovascular Institute and the Marie\u2010Jos\u00e9e and Henry R. Kravis Center for Cardiovascular Health, Division of Cardiology, Department of Medicine Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dane","family":"Wukich","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luke","family":"Perry","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery University of Texas Health Science Center  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Sideman","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery University of Texas Health Science Center  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence A.","family":"Lavery","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery University of Texas Health Science Center  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"issue":"2","key":"e_1_2_8_2_1","first-page":"V","article-title":"Is Diabetes Becoming the Biggest Epidemic of the Twenty\u2010First Century?","volume":"1","author":"Tabish S. 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