{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:15:19Z","timestamp":1773011719006,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":53,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study investigated the isolated and combined effects of sericin and low\u2010level laser photobiomodulation (PBM) on the healing of experimentally induced second\u2010degree burns in male Wistar rats. Sericin has previously been associated with enhanced fibroblast migration and improved reepithelialization, while PBM has shown anti\u2010inflammatory potential. To assess their therapeutic value, 60 rats were randomised into six groups: untreated control (CON), silver sulfadiazine (SUL), sericin cream (SER), PBM alone, SUL\u2009+\u2009PBM and SER\u2009+\u2009PBM. Burn injuries were produced using a heated metal instrument applied for 3\u2009s, and animals were euthanized 14\u2009days later. Macroscopic photography, photothermography and histomorphometric analyses were performed. Statistical tests using generalised linear models were set at\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.05. A significant temperature difference between initial (AV0) and follow\u2010up (AV1) evaluations was observed, although granulation tissue formation did not differ across groups. Collagen analysis revealed that SER, PBM, SUL\u2009+\u2009PBM and SER\u2009+\u2009PBM groups presented higher collagen scores than controls (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). The SER\u2009+\u2009PBM treatment was particularly effective, showing the greatest proportion of type I collagen and statistical superiority over the other interventions (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Molecular evaluations demonstrated reduced levels of tumour necrosis factor alpha, thiobarbituric acid reactive substances and catalase, especially in groups receiving PBM in combination with either sericin or sulfadiazine, suggesting a decrease in oxidative stress. Overall, the results indicate that both sericin and PBM positively influence tissue repair, with combined therapy\u2014particularly SER\u2009+\u2009PBM\u2014yielding enhanced collagen deposition and biochemical markers consistent with improved healing. Further studies are warranted to clarify the underlying biological mechanisms driving these outcomes.\n                  <\/jats:p>","DOI":"10.1111\/wrr.70135","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:33:18Z","timestamp":1772969598000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Photobiomodulation and Sericin in the Treatment of Second\u2010Degree Burns Induced in Wistar Rats"],"prefix":"10.1111","volume":"34","author":[{"given":"Lilian","family":"de Ara\u00fajo Pradal","sequence":"first","affiliation":[{"name":"Universidade Estadual do Oeste do Paran\u00e1 \u2013 UNIOESTE  Cascavel Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa Munir Mustafa","family":"Dahleh","sequence":"additional","affiliation":[{"name":"Universidade Federal do Pampa \u2013 UNIPAMPA  Itaqui Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9724-7469","authenticated-orcid":false,"given":"Marina","family":"Prigol","sequence":"additional","affiliation":[{"name":"Universidade Federal do Pampa \u2013 UNIPAMPA  Itaqui Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo Petri","family":"Guerra","sequence":"additional","affiliation":[{"name":"Universidade Federal do Pampa \u2013 UNIPAMPA  Itaqui Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celeste","family":"da Rocha Paiva","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Oeste do Paran\u00e1 \u2013 UNIOESTE  Cascavel Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tha\u00eds Caroline","family":"Schnaufer","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Oeste do Paran\u00e1 \u2013 UNIOESTE  Cascavel Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucin\u00e9ia","family":"de F\u00e1tima Chasko Ribeiro","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Oeste do Paran\u00e1 \u2013 UNIOESTE  Cascavel Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose Meire","family":"Costa","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Oeste do Paran\u00e1 \u2013 UNIOESTE  Cascavel Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0565-2019","authenticated-orcid":false,"given":"Gladson Ricardo Flor","family":"Bertolini","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Oeste do Paran\u00e1 \u2013 UNIOESTE  Cascavel Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2017.26.1.5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2007.04.009"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-014-1612-5"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01105.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000002908"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0961-2"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-0358.101319"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0000000000000355"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2018.05.014"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2016.03.029"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8175701"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-013-1371-4"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2005.00200.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms11052200"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiosc.2008.12.012"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000553600.97572.d2"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-018-2633-3"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-014-1573-9"},{"key":"e_1_2_10_20_1","unstructured":"Manual de Anestesia e Analgesia do Biot\u00e9rio da Unifal\u2010MG 1\u2010Anestesia em Animais de Laborat\u00f3rio chrome\u2010extension:\/\/efaidnbmnnnibpcajpcglclefindmkaj\/https:\/\/ww3.icb.usp.br\/wp\u2010content\/uploads\/2023\/09\/Guia_Anestesia_Analgesia_CEUA_UNIFESP_14_06_2022.pdf."},{"key":"e_1_2_10_21_1","unstructured":"D. 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