{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:31:01Z","timestamp":1777948261184,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Chronic wounds affect 10.5 million Americans annually and are projected to cost over $30 billion by 2030. Adult chronic wounds are well characterised, yet the paediatric burden remains understudied, hindering cost\u2010effective management. Objectives were to (1) characterise epidemiology (prevalence, demographics, aetiology and comorbidities) and (2) quantify the economic impact of their hospitalisations. A retrospective cohort analysis of the 2017\u20132020 National Inpatient Sample (NIS), a 20% stratified sample of U.S. community hospital discharges identified patients \u2264\u200918\u2009years with primary or secondary ICD\u201010\u2010CM codes for chronic pressure ulcers, non\u2010pressure ulcers, or osteomyelitis (haematogenous cases excluded). Variables included wound type, demographics, hospital characteristics (admission type, discharge disposition and region) and comorbidities. Outcomes comprised wound prevalence, length of stay and total inpatient costs (adjusted to 2020 USD). Multivariable models evaluated factors associated with costs. Of 45,645 paediatric chronic wound admissions, osteomyelitis was most common (47%\u201388%) and pressure ulcers appeared in 45% of secondary diagnoses. Males represented 61%; 55% were Medicaid beneficiaries. Median LOS was 8\u2009days (IQR 3\u201316) for pressure ulcers and 4\u2009days (IQR 3\u20137) for osteomyelitis. Four\u2010year costs totalled $3.51 billion (\u2248$900 million annually), highest for head wounds ($5397\/day) and pressure ulcers ($4668\/day). Cerebral palsy (20%) and malnutrition (3%) were frequent comorbidities. Fourteen percent required home healthcare; inpatient mortality was 2%. Paediatric chronic wounds, predominantly osteomyelitis with complex comorbidities, incur high costs and prolonged hospitalisations. Tailored prevention and management strategies are essential to improve outcomes and reduce this healthcare burden.<\/jats:p>","DOI":"10.1111\/wrr.70150","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T06:26:21Z","timestamp":1775024781000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Burden of Paediatric Chronic Wounds: A Nationwide Analysis"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0910-153X","authenticated-orcid":false,"given":"Ayesha A.","family":"Qureshi","sequence":"first","affiliation":[{"name":"Center for Regenerative Medicine Abigail Wexner Research Institute at Nationwide Children's Hospital  Columbus Ohio USA"},{"name":"Department of Plastic and Reconstructive Surgery Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2191-4824","authenticated-orcid":false,"given":"Catherine C.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Center for Regenerative Medicine Abigail Wexner Research Institute at Nationwide Children's Hospital  Columbus Ohio USA"},{"name":"Department of Plastic and Reconstructive Surgery Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seraph Han\u2010Yin","family":"Lin","sequence":"additional","affiliation":[{"name":"Center for Regenerative Medicine Abigail Wexner Research Institute at Nationwide Children's Hospital  Columbus Ohio USA"},{"name":"Department of Plastic and Reconstructive Surgery Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Vasko","sequence":"additional","affiliation":[{"name":"Center for Regenerative Medicine Abigail Wexner Research Institute at Nationwide Children's Hospital  Columbus Ohio USA"},{"name":"Department of Plastic and Reconstructive Surgery Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingzhen","family":"Yang","sequence":"additional","affiliation":[{"name":"Center for Injury Research and Policy Abigail Wexner Research Institute at Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard E.","family":"Kirschner","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny C.","family":"Barker","sequence":"additional","affiliation":[{"name":"Center for Regenerative Medicine Abigail Wexner Research Institute at Nationwide Children's Hospital  Columbus Ohio USA"},{"name":"Department of Plastic and Reconstructive Surgery Nationwide Children's Hospital  Columbus Ohio USA"},{"name":"Pediatric Comprehensive Wound Program Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2021.0026"},{"issue":"2","key":"e_1_2_10_3_1","first-page":"30","article-title":"Surgical Management of Chronic Wounds","volume":"99","author":"Johnston B. R.","year":"2016","journal-title":"Rhode Island Medical Journal"},{"key":"e_1_2_10_4_1","first-page":"39","volume-title":"Human Wounds and Its Burden: An Updated Compendium of Estimates","author":"Sen C. 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M.","year":"2007","journal-title":"Ostomy\/Wound Management"},{"key":"e_1_2_10_13_1","unstructured":"Quality A.f.H.R.a \u201cHCUP National Inpatient Sample (NIS) Overview \u201d 2024 https:\/\/hcup\u2010us.ahrq.gov\/nisoverview.jsp."},{"key":"e_1_2_10_14_1","unstructured":"Statistics B.o.L \u201cConsumer Price Index (CPI) Data \u201d 2024 https:\/\/www.bls.gov\/cpi\/data.htm."},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-022-00663-w"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000003067"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imu.2019.100247"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.57.030502.090720"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.295.5559.1487"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000003325"},{"issue":"9","key":"e_1_2_10_21_1","first-page":"44","article-title":"A Retrospective Comparison of Clinical Outcomes and Medicare Expenditures in Skilled Nursing Facility Residents With Chronic Wounds","volume":"56","author":"DaVanzo J. 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