{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:54:18Z","timestamp":1788386058938,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic non\u2010healing skin ulcers are one of the most important clinical challenges, usually refusing conventional treatments. The applications of autologous platelet concentrates include platelet\u2010rich plasma and platelet\u2010rich fibrin, which enhance healing properties by accelerating wound healing by growth factor release. This randomised, prospective clinical trial included 36 patients aged between 18 and 65\u2009years suffering from chronic non\u2010healing ulcers. They were then randomly allocated into three treatment groups: Group A (PRP), Group B (PRF) and Group C (Conventional treatment). PRP and PRF were acquired by standardising blood collection from the autologous blood samples, after which they were subjected to centrifugation and applied weekly for eight sessions. Ulcer area reduction, healing rates as well as pain scores were assessed at baseline, 4\u2009weeks and 8\u2009weeks after baseline using ImageJ software and the Visual Analogue Scale (VAS). PRF more evidently repaired ulcers than PRP, with a mean reduction in surface area of 81.4% at 8\u2009weeks, compared with 47.6% in PRP and 26.1% in controls (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Complete healing was noted among 58.3% in PRF, 41.7% in PRP and 0% in controls. Pain scores among the different groups had no significant differences, and no adverse events were noted during the study. PRF was superior to PRP and conventional therapy in healing chronic diabetic and venous ulcers, which can be attributed to its longer duration of growth factor release with a fibrin scaffold. PRF is a low\u2010cost, autologous and accessible regenerative alternative in the management of chronic wounds.\n                  <\/jats:p>","DOI":"10.1111\/wrr.70151","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T13:00:09Z","timestamp":1774875609000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative Efficacy of Platelet\u2010Rich Plasma, Platelet\u2010Rich Fibrin, and Conventional Therapy in Chronic Non\u2010Healing Skin Ulcers: A Randomised Clinical Trial"],"prefix":"10.1111","volume":"34","author":[{"given":"Eman Mohamed","family":"Salah","sequence":"first","affiliation":[{"name":"Department of Dermatology, Andrology, Sexual Medicine and STDs, Faculty of Medicine Helwan University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2624-2054","authenticated-orcid":false,"given":"Mohamed Aboshabana","family":"Hussein","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Faculty of Medicine Kafrelsheikh University  Kafr el\u2010Sheikh Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba Mahmoud","family":"Diab","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology, Faculty of Medicine Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.51449"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2023.0150"},{"issue":"1","key":"e_1_2_8_4_1","first-page":"60","article-title":"The Current Situation for Non\u2010Healing Wounds","volume":"19","author":"Blanchette V.","year":"2021","journal-title":"Wound Healing and Care"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615439"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10010029"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14051556"},{"key":"e_1_2_8_8_1","first-page":"75","article-title":"Efficacy of Vacuum Assisted Closure Therapy in Healing Diabetic Foot","volume":"28","author":"Khan K.","year":"2025","journal-title":"Pakistan Armed Forces Medical Journal"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom14101248"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deae108.661"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2024.01.002"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-024-05254-x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14326"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/413604"},{"key":"e_1_2_8_15_1","first-page":"172","article-title":"Efficacy of Autologous Platelet\u2010Rich Fibrin in Chronic Cutaneous Ulcer: A Randomized Controlled Trial","volume":"3","author":"Shreyas N. S.","year":"2017","journal-title":"IP Indian J Clin Exp Dermatol"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.25259\/IJDVL_1050_20"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.idoj_282_21"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)90884-8"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.5758\/vsi.2019.35.1.22"},{"issue":"9","key":"e_1_2_8_20_1","article-title":"Role of Autologous Platelet\u2010Rich Fibrin in Chronic Non\u2010Healing Ulcers With Various Etiologies in a Tertiary Care Rehabilitation Centre: A Case Series","volume":"16","author":"Sharma A. 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