{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:31:04Z","timestamp":1777948264679,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"vor","delay-in-days":49,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R44AR082787\u201001A1"],"award-info":[{"award-number":["1R44AR082787\u201001A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Reconstruction of full\u2010thickness wounds remains a major clinical challenge. Full\u2010thickness skin grafts (FTSG) are considered an ideal reconstructive option as they reconstitute both epidermal and dermal layers of skin; however, their use is limited by donor site availability and potential donor site morbidity. Dermal regeneration templates (DRTs) were introduced decades ago to reduce dermal harvesting needs and promote formation of a \u2018neodermal\u2019 layer, improving both functional and cosmetic outcomes. However, current DRTs are limited by slow vascularization, typically requiring 2\u20134\u2009weeks for integration. To address these limitations, we developed DermiSphere\n                    <jats:italic>h<\/jats:italic>\n                    DRT, a\n                    <jats:italic>hydrogel<\/jats:italic>\n                    dermal regeneration template, a biphasic collagen\u2010based matrix combining a type I collagen hydrogel with densely packed collagen microspheres. The resulting differential\u2010density interfaces generate a gradient microstructure that supports efficient cellular infiltration and neovascularization. Using a swine model, we evaluated early host response and vascular invasion into\n                    <jats:italic>h<\/jats:italic>\n                    DRT without an overlying graft. By Postoperative Day (POD) 3,\n                    <jats:italic>h<\/jats:italic>\n                    DRT was fully integrated with the wound bed and resistant to manual shear, whereas the market\u2010leading DRT (MLT) showed minimal adherence. Quantitative histology revealed significantly greater cellular and endothelial invasion in\n                    <jats:italic>h<\/jats:italic>\n                    DRT, with CD31+ vascular channels penetrating nearly halfway through the construct. By POD 7,\n                    <jats:italic>h<\/jats:italic>\n                    DRT generated thicker neodermal tissue with extensive vascular networks extending into new granulation tissue. By POD 10,\n                    <jats:italic>h<\/jats:italic>\n                    DRT exhibited organised collagen remodelling and interconnected vertical and horizontal vessel growth, while MLT remained incompletely incorporated. These results demonstrate that\n                    <jats:italic>h<\/jats:italic>\n                    DRT's unique microarchitecture accelerates cellular infiltration and neovascularization, enabling faster, more reliable formation of a vascularized neodermal layer for full\u2010thickness skin repair.\n                  <\/jats:p>","DOI":"10.1111\/wrr.70152","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T04:26:28Z","timestamp":1776659188000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enhanced Early Vascularization and Tissue Formation in a Biphasic Collagen Hydrogel Dermal Regeneration Template"],"prefix":"10.1111","volume":"34","author":[{"given":"Derek","family":"Luong","sequence":"first","affiliation":[{"name":"FesariusTherapeutics Inc  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachael","family":"Cohen","sequence":"additional","affiliation":[{"name":"FesariusTherapeutics Inc  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9773-1170","authenticated-orcid":false,"given":"Adam","family":"Weisel","sequence":"additional","affiliation":[{"name":"FesariusTherapeutics Inc  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravyn","family":"Dorleus","sequence":"additional","affiliation":[{"name":"FesariusTherapeutics Inc  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Yao","sequence":"additional","affiliation":[{"name":"Veritas Dermatopathology PLLC  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Novotney","sequence":"additional","affiliation":[{"name":"Center for Animal Resources and Education (C.A.R.E.) Montefiore Medical Center  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason A.","family":"Spector","sequence":"additional","affiliation":[{"name":"FesariusTherapeutics Inc  New York New York USA"},{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery Weill Cornell Medicine  New York New York USA"},{"name":"Nancy E. and Peter C. Meinig School of Biomedical Engineering Cornell University  Ithaca New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulia","family":"Sapir\u2010Lekhovitser","sequence":"additional","affiliation":[{"name":"FesariusTherapeutics Inc  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1085-5629(03)00079-8"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/563493"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70164-B"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1090820X11417576"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000005572"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000005674"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200108000-00015"},{"key":"e_1_2_12_9_1","volume-title":"Integra Bilayer Matrix Wound Dressing\u2014Indication of Use","author":"Integra LifeSciences","year":"2004"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1693401"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000002869"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000002622"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.04.027"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.3356"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.13102"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e318230c5f1"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2019.07.021"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198110000-00005"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2007.08.011"},{"issue":"3","key":"e_1_2_12_20_1","first-page":"567","article-title":"Three\u2010Year Experience With Integra Dermal Regenerative Template as a Reconstructive Tool","volume":"39","author":"Ben\u2010Nakhi M. E.","year":"2020","journal-title":"Egyptian Journal of Surgery"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000003516"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13637"},{"key":"e_1_2_12_23_1","volume-title":"Grabb and Smith's Plastic Surgery","author":"Thorne C. H.","year":"2013"}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.70152","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/wrr.70152","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.70152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T06:17:01Z","timestamp":1777789021000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.70152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/wrr.70152"],"URL":"https:\/\/doi.org\/10.1111\/wrr.70152","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-10-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70152"}}