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Currently, only limited therapeutic options are available to address this condition. This study investigates the potential of soluble CD83 (sCD83), an immunomodulatory molecule, to facilitate wound healing in a human in\u00a0vitro wound model. This model incorporates keratinocytes, fibroblasts, and macrophages in a three\u2010dimensional skin construct and was exposed to chronic wound fluid (CWF) to induce an inflammatory and impaired\u2010healing environment. Treatment with sCD83 resulted in a significant acceleration of wound closure, enhanced macrophage polarisation towards a pro\u2010regenerative phenotype, and an increase in the production of growth factors such as VEGF and TGF\u2010\u03b2. These effects were also observed under inflammatory conditions induced by CWF, which otherwise impaired healing and sustained a pro\u2010inflammatory environment. Furthermore, sCD83 enhanced markers associated with epidermal stem cell activity and diminished the expression of pro\u2010inflammatory mediators, underscoring its immunomodulatory and pro\u2010regenerative properties within this human 3D in\u00a0vitro model. Together, these results demonstrate that sCD83 can attenuate inflammatory responses and improve regenerative processes in a CWF\u2010induced impaired healing environment in\u00a0vitro. Our findings provide the basis for further preclinical studies to unravel the clinical potential of sCD83 as a novel treatment option for chronic and hard\u2010to\u2010heal wounds.<\/jats:p>","DOI":"10.1111\/wrr.70158","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T04:09:50Z","timestamp":1777003790000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Soluble\n                    <scp>CD83<\/scp>\n                    Accelerates Wound Healing and Attenuates Inflammatory Responses Induced by Chronic Wound Fluid in a Human\n                    <scp>3D<\/scp>\n                    in Vitro Wound Healing Model"],"prefix":"10.1111","volume":"34","author":[{"given":"Christian","family":"Hollard","sequence":"first","affiliation":[{"name":"Department of Immune Modulation, Uniklinikum Erlangen Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen 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