{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T09:43:37Z","timestamp":1786182217096,"version":"build-2736575974"},"reference-count":63,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Major lower\u2010limb amputation often leads to wound complications that delay recovery and prosthetic use. Negative Pressure Wound Therapy (NPWT) has been suggested to improve outcomes, but evidence is inconsistent. The objective of this study is to compare NPWT with standard wound therapy in fresh amputation stumps. A systematic review and meta\u2010analysis following PRISMA and Cochrane guidelines included randomised and controlled observational trials. Primary outcomes were wound complications, including surgical\u2010site infections (SSI) and wound dehiscence. Secondary outcomes included re\u2010amputation, healing, and resource use. Seventeen papers including over 6745 patients were analysed. NPWT significantly reduced total wound complications (RR 0.49, 95% CI 0.37\u20130.66) and SSIs (RR 0.50, 95% CI 0.27\u20130.90), including both superficial (RR 0.30, 95% CI 0.12\u20130.73) and deep infections (RR 0.26, 95% CI 0.11\u20130.63). The secondary amputation risk was lowered by one\u2010third (RR 0.67, 95% CI 0.50\u20130.89). Wound dehiscence risk decreased (RR 0.53, 95% CI 0.30\u20130.94). Mortality, readmission, and hospital stay showed no significant differences between groups. Healing outcomes strongly favoured NPWT: mean time to \u2265\u200976% granulation was shortened by 25\u2009days, while complete closure occurred nearly two weeks earlier. Kaplan\u2013Meier reconstruction confirmed that NPWT accelerated wound maturation by 77% (HR 0.23, 95% CI 0.12\u20130.44). Economic evaluations, though limited, indicated fewer dressing changes, reduced outpatient visits, and overall cost savings. NPWT after major lower\u2010limb amputation halves wound complications and infections, lowers re\u2010amputation, and accelerates healing. Despite unchanged systemic outcomes, the local benefits are clinically significant, supporting its use in standard post\u2010amputation care.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    CRD420251088214.\n                  <\/jats:p>","DOI":"10.1111\/wrr.70162","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T03:49:37Z","timestamp":1778298577000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Negative Pressure Wound Therapy in Managing Lower Limb Amputation; An Updated Systematic Review and Meta\u2010Analysis With Individual Patients Data Meta\u2010Analysis and\n                    <scp>GRADE<\/scp>\n                    Assessment"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3739-4045","authenticated-orcid":false,"given":"Abdullah","family":"Elrefae","sequence":"first","affiliation":[{"name":"Northwick Park Hospital  Harrow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Elghouneimy","sequence":"additional","affiliation":[{"name":"Manchester University NHS Foundation Trust  Manchester UK"},{"name":"Membership of the Royal College of Surgeons of England  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirna Morad","family":"Mashhour","sequence":"additional","affiliation":[{"name":"Swansea Bay University Health Board Hospitals  Swansea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed H.","family":"Khater","sequence":"additional","affiliation":[{"name":"Hull University Teaching Hospitals  Hull 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University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Amgad","family":"Seddek","sequence":"additional","affiliation":[{"name":"Al\u2010Hussein University Hospital, Faculty of Medicine, Al\u2010Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar Ahmed","family":"Abdelwahab","sequence":"additional","affiliation":[{"name":"Al\u2010Hussein University Hospital, Faculty of Medicine, Al\u2010Azhar University  Cairo 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