{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:41:32Z","timestamp":1788493292829,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    To estimate the effect of topical oxygen therapy (TOT) on complete wound closure in diabetic foot ulcers (DFUs) at 12\u2009weeks. We systematically reviewed randomised controlled trials in adults with DFUs comparing TOT to sham or standard care. Study selection and data extraction followed predefined criteria, with uncertainties discussed between the authors. Risk of bias was assessed with RoB 2. The primary outcome was complete closure at 12\u2009weeks. Risk ratios (RRs) were pooled using a Mantel\u2013Haenszel fixed\u2010effect model with\n                    <jats:italic>\u03c7<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    and\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    to assess heterogeneity. Random\u2010effects sensitivity analyses were performed, including DerSimonian\u2013Laird and Hartung\u2013Knapp adjustment given the small number of studies. Three trials (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009171 TOT;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009154 control) reported 12\u2010week closure and were pooled. TOT increased complete closure (RR 1.53, 95% CI 1.14\u20132.05). Heterogeneity was low (\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u224824%). The DerSimonian\u2013Laird random\u2010effects model produced a similar point estimate (RR 1.50, 95% CI 1.07\u20132.10), while Hartung\u2013Knapp adjustment yielded wider uncertainty. No zero cells were present; the prespecified continuity correction was not required. Across randomised trials with a 12\u2010week assessment, TOT used alongside standard care increases the likelihood of complete closure in DFUs, with low between\u2010study heterogeneity. These conclusions are based on three pooled randomised trials, and conservative Hartung\u2013Knapp sensitivity analysis widened uncertainty, reflecting the limited size of the evidence base. However, with few trials, uncertainty remains; larger, well\u2010reported studies with standardised endpoints and blinded outcome verification are needed to refine precision and compare delivery approaches.\n                  <\/jats:p>","DOI":"10.1111\/wrr.70170","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T03:25:41Z","timestamp":1779852341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Topical Oxygen Therapy for Diabetic Foot Ulcers: Updated\u00a0Evidence From Randomised Trials"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1196-539X","authenticated-orcid":false,"given":"George","family":"Theodorakopoulos","sequence":"first","affiliation":[{"name":"Wound and Foot Specialist  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1887-9175","authenticated-orcid":false,"given":"David G.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Southwestern Academic Limb Salvage Alliance (SALSA)  Los Angeles California USA"},{"name":"Center to Stream Healthcare in Place (C2SHiP)  Alexandria Virginia USA"},{"name":"Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615439"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13569"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci22-0043"},{"issue":"6","key":"e_1_2_12_5_1","first-page":"1293","article-title":"Efficacy and Safety of Topical Oxygen Therapy for Diabetic Foot Ulcers: An Updated Systematic Review and Meta\u2010Analysis of Randomized Controlled Trials","volume":"19","author":"Sun X.","year":"2022","journal-title":"International Wound Journal"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1932296817695574"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2024.0026"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.2478\/fon-2023-0010"},{"key":"e_1_2_12_9_1","volume-title":"StatPearls [Internet]","author":"Kahle A. C.","year":"2025"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050212"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jccw.2014.12.003"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.108743"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2024.33.2.90"},{"key":"e_1_2_12_14_1","volume-title":"IWGDF Guidelines on Interventions to Enhance Healing of Foot Ulcers in People With Diabetes: 2023 Update","author":"Chen P.","year":"2023"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2022.0041"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.14585"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hsr.2022.100028"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.14960"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2021.30.Sup5.S7"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12490"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39500.677199"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.2196\/64016"},{"key":"e_1_2_12_25_1","volume-title":"RStudio: Integrated Development Environment for R","author":"Posit Team","year":"2025"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-0476"}],"updated-by":[{"DOI":"10.1111\/wrr.70195","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000}}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.70170","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/wrr.70170","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.70170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T09:30:23Z","timestamp":1786181423000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.70170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/wrr.70170"],"URL":"https:\/\/doi.org\/10.1111\/wrr.70170","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70170"}}