{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T05:35:28Z","timestamp":1789796128942,"version":"4.0.1"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":52,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The purpose of this systematic review was to determine whether the addition of antimicrobial peptides (AMPs) to dressing materials enhances their wound healing capabilities when applied to\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    \u2010infected wounds in rodent models. The primary objective was not to derive definitive efficacy conclusions, but to systematically assess the quality, consistency, and translational readiness of existing in\u00a0vivo evidence for AMP\u2010based dressings in excisional wound models to inform future in\u00a0vivo experimental design. The systematic review was performed according to Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses guidelines. Two authors independently completed the literature search using three electronic databases and two databases for grey literature. Studies were included if they met pre\u2010established inclusion criteria. Rate of wound healing was considered as the primary outcome; the secondary outcome involved histological analyses of tissue samples of the wounds. Risk of bias was assessed using the SYRCLE risk of bias tool for animal studies and meta\u2010analysis was performed with pooled data from three or more studies reporting the same outcome, employing a random effects model. By the final timepoint, the meta\u2010analyses identified a significant increase in wound healing rate in both rats (mean difference\u2009=\u20092.79%, 95% CI [1.52%, 4.06%],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001) and mice (mean difference\u2009=\u200932.30%, 95% CI [18.06%, 46.54%],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.00001) exposed to AMP\u2010based dressing materials compared to AMP\u2010free carrier materials. The significantly improved wound healing rates provide promising evidence that these materials are suitable for promoting the wound healing of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    \u2010infected wounds that may be investigated further in clinical studies.\n                  <\/jats:p>","DOI":"10.1111\/wrr.70183","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:17:19Z","timestamp":1782188239000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["In Vivo Wound Healing Effects of Antimicrobial Peptide\u2010Based Dressings for\n                    <i>S. aureus<\/i>\n                    \u2010Infected Wounds\u2014A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9269-5027","authenticated-orcid":false,"given":"Lea","family":"Rodge","sequence":"first","affiliation":[{"name":"Biomaterials Research Group, School of Metallurgy and Materials, College of Engineering and Physical Sciences, University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artemis","family":"Stamboulis","sequence":"additional","affiliation":[{"name":"Biomaterials Research Group, School of Metallurgy and Materials, College of Engineering and Physical Sciences, University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6790-8433","authenticated-orcid":false,"given":"Sarah A.","family":"Kuehne","sequence":"additional","affiliation":[{"name":"Nottingham Trent University, School of Science and Technology  Nottingham 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Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Resistance RoA \u201cTackling Drug\u2010Resistant Infections Globally: Final Report and Recommendations: Review on Antimicrobial Resistance 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