{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:21:18Z","timestamp":1787808078798,"version":"build-2784847793"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18K16982"],"award-info":[{"award-number":["JP18K16982"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP24K12844"],"award-info":[{"award-number":["JP24K12844"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The detrimental effects of dysfunctional mitochondria on cells and tissues have been shown to improve by healthy mitochondria transplantation. However, the feasibility of intercellular mitochondrial transfer for wound healing remains uncertain. This study examined whether healthy mitochondria transplantation promoted the healing of acute wounds. Isolated mitochondria derived from primary cultured normal human dermal fibroblasts were administered to primary cells of the same lineage, with confirmed cell uptake. Wound closure rate in in\u00a0vitro scratch wound healing assays increased in a dose\u2010dependent manner and was attenuated by treatment with the mitochondrial function inhibitor antimycin A. Gene expression analysis revealed significant increases in the cell proliferation markers\n                    <jats:italic>MKI67<\/jats:italic>\n                    and\n                    <jats:italic>PCNA<\/jats:italic>\n                    , although no consistent changes in migration\u2010related genes were observed. Cell proliferation rate increased to a maximum average of 1.4\u2010fold after isolated mitochondrial administration, which was attenuated by antimycin A treatment. To verify the in\u00a0vivo effects of isolated mitochondrial transplantation, mitochondria were obtained from mouse livers, and wound closure rate was analysed using a mouse wound healing model. The number of days to wound closure was significantly shortened in a dose\u2010dependent manner, and this gain was attenuated by antimycin A. Our findings demonstrate that mitochondrial transplantation accelerates acute wound closure and enhances fibroblast proliferative activity. The observed increase in cell proliferation may contribute, at least in part, to the beneficial effects of mitochondrial transplantation on wound healing. These findings provide insight into the therapeutic potential of mitochondrial transplantation as a novel strategy for wound repair.\n                  <\/jats:p>","DOI":"10.1111\/wrr.70192","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T07:59:02Z","timestamp":1784879942000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitochondrial Transplantation Increases Dermal Fibroblast Proliferation and Accelerates Acute Wound Closure"],"prefix":"10.1111","volume":"34","author":[{"given":"Ikkei","family":"Takashimizu","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miho","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Yuzuriha","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(75)80001-8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)90006-4"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2307\/3570892"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/292154a0"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5391.1145"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.024"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.11.019"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.2.720"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709866"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0892-368"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92560-3"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104343"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.02.014"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)92366-0"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0924"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/331717a0"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2003.12.045"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.2000.020305.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.8.6.519"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/3108"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1082889"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/295605a0"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90423-0"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510511103"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21539-y"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00883.2012"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2736"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5605"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2015.12.003"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-07-655860"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00241"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-024-01125-5"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(70)90070-3"},{"issue":"2","key":"e_1_2_11_35_1","first-page":"561","article-title":"The Effect of Varying Ambient Oxygen Tensions on Wound Metabolism and Collagen Synthesis","volume":"135","author":"Hunt T. 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