{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:22:57Z","timestamp":1787808177194,"version":"build-2784847793"},"reference-count":82,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":42,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Topical treatment of burn wounds remains challenging because eschar formation, inflammation and impaired vascularization can limit drug penetration and tissue repair. Here, we introduce a flexible large\u2010area microneedle patch for sustained local delivery of extracellular matrix\u2010derived peptides to deep partial\u2010thickness burn wounds. The microneedles were composed of cellulose acetate phthalate and hydroxypropyl methylcellulose and included a transparent water\u2010soluble backing layer to aid placement and allow dissolution after application. The patch delivered two peptides with previously reported biological activity: TSN6, associated with angiogenic responses and TSN18, associated with cell proliferation and epithelial repair. The microneedles retained sharp conical geometry after peptide loading, showed sufficient compressive strength for skin insertion and produced consistent microchannels in ex\u00a0vivo porcine skin. In\u00a0vitro studies showed peptide\u2010dependent release over 48\u2009h: TSN18 reached approximately 50% release within 12\u2009h and exceeded 80% release by 48\u2009h, whereas TSN6 was released more slowly, reaching 45% when loaded alone and 58% when co\u2010loaded with TSN18. In a porcine deep partial\u2010thickness burn model, TSN18\u2010treated wounds showed lower burn depth than SSD\u2010treated wounds at day 4 (1174\u2009\u00b1\u200935 vs. 1628\u2009\u00b1\u2009178\u2009\u03bcm,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Co\u2010delivery of TSN6 and TSN18 preserved more dermis than the scrambled peptide control (1667\u2009\u00b1\u2009134 vs. 938\u2009\u00b1\u2009194\u2009\u03bcm,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) and increased neoepidermal thickness at day 20 compared with scrambled peptide and SSD controls (417\u2009\u00b1\u200945 vs. 237\u2009\u00b1\u200925 and 265\u2009\u00b1\u200916\u2009\u03bcm, respectively). Although consistent improvements in macroscopic wound closure and re\u2010epithelialization were not observed across peptide\u2010treated groups, these results show that microneedle\u2010mediated peptide delivery can improve selected tissue\u2010level measures of burn injury and epidermal repair.\n                  <\/jats:p>","DOI":"10.1111\/wrr.70198","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T05:55:22Z","timestamp":1786600522000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microneedle\u2010Mediated Delivery of Extracellular Matrix\u2010Inspired Peptides for Mitigation of Burn Wound Progression and Support of Tissue Repair"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3884-3236","authenticated-orcid":false,"given":"Danilo M.","family":"dos Santos","sequence":"first","affiliation":[{"name":"Department of Electrical and Computer 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Christy","sequence":"additional","affiliation":[{"name":"United States Army Institute of Surgical Research  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5161-1974","authenticated-orcid":false,"given":"Thomas N.","family":"Darling","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine Uniformed Services University  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira M.","family":"Herman","sequence":"additional","affiliation":[{"name":"Department of Developmental, Molecular, and Chemical Biology Tufts University, Graduate School of Biomedical Sciences  Boston Massachusetts USA"},{"name":"Center for Innovations in Wound Healing Research Tufts University School of Medicine  Boston Massachusetts 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A.\u2010O.Varon A. H.Carlsson L. E.Cooper et\u00a0al. Evaluation of Topical Off\u2010The\u2010Shelf Therapies to Improve Prolonged Field Care of Burn\u2010Injured Service Members. 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