{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:21:12Z","timestamp":1787808072605,"version":"build-2784847793"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":50,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20232BAB216055"],"award-info":[{"award-number":["20232BAB216055"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Chinese medicinal honey (CMH) is traditionally used for wounds, but its mechanisms in diabetic wounds are unclear. This study aimed to investigate the active components of CMH and the molecular mechanisms underlying its promotion of wound healing in individuals with diabetes to provide a preliminary experimental basis for its clinical application. The main components of CMH were analysed using ultra\u2010performance liquid chromatography\u2013quadrupole time\u2010of\u2010flight mass spectrometry (UPLC\u2010Q\u2010TOF\/MS). An integrated strategy combining network pharmacology, transcriptomics, molecular docking and animal experiments was applied. A db\/db diabetic mouse model was used to evaluate CMH in diabetic wound healing.\u00a0Histopathology, immunohistochemistry, qRT\u2010PCR and western blotting were performed to assess anti\u2010inflammatory, antioxidant and pro\u2010angiogenic effects. Fifty\u2010two major CMH components, mainly flavonoids and phenolic acids, were identified. Network pharmacology and transcriptomics showed that CMH targets epidermal growth factor receptor (EGFR), interleukin (IL)\u20101\u03b2, matrix metallopeptidase 9 (MMP9) and prostaglandin\u2010endoperoxide synthase 2 (PTGS2), with significant\u00a0enrichment in the IL\u201017 signalling pathway. Molecular docking validated a strong binding affinity between CMH components and key targets, including IL\u201017A and NF\u2010\u03baB. In\u00a0vivo findings suggest that CMH markedly accelerates wound healing in diabetic mice, reduces inflammation and oxidative stress, promotes collagen deposition and angiogenesis and suppresses the activity of the IL\u201017A\/NF\u2010\u03baB pathway. This study provides a preliminary experimental basis of CMH. CMH\u00a0supports diabetic wound healing through a multi\u2010component, multi\u2010target mechanism, primarily by inhibiting the IL\u201017A\/NF\u2010\u03baB signalling pathway, thereby attenuating inflammation and oxidative stress and promoting angiogenesis and tissue repair.<\/jats:p>","DOI":"10.1111\/wrr.70199","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T07:27:10Z","timestamp":1787210830000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrating Transcriptomics, Network Pharmacology, Molecular Docking and Experimental Validation to Explore the Pharmacological Mechanisms of Chinese Medicinal Honey in Treating Diabetic Wounds"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1536-4709","authenticated-orcid":false,"given":"Yungang","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Burns and Plastic Surgery, Beijing Jishuitan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, Beijing Jishuitan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhi","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, Beijing Jishuitan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, Beijing Jishuitan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, Beijing Jishuitan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1088-8094","authenticated-orcid":false,"given":"Weili","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, Beijing Jishuitan Hospital Capital Medical University  Beijing 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