{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T09:36:51Z","timestamp":1793093811137,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic lower limb wounds are especially difficult to heal when further vascular reconstruction is not feasible, yet evidence for noninvasive adjunctive therapies in this population remains limited. Intermittent vacuum therapy (IVT) exposes the limb to alternating negative and positive pressure, but clinical wound\u2010healing evidence is scarce. We evaluated whether adjunctive IVT was associated with faster complete healing in a single\u2010centre retrospective age\u2010 and sex\u2010matched cohort. Ninety\u2010four patients treated between December 2019 and June 2022 were included: 47 received IVT plus standard wound care and 47 received standard wound care alone. IVT comprised three 30\u201340\u2010min sessions weekly. Complete epithelialization was the event; unhealed wounds were censored at the last documented follow\u2010up. Kaplan\u2013Meier analysis and Cox regression stratified by wound aetiology were used. Complete healing occurred in 36 of 47 IVT\u2010treated wounds (76.6%) and 23 of 47 controls (48.9%); the Kaplan\u2013Meier median time to healing was 4.0 versus 17.0\u2009months. After multivariable adjustment, IVT was associated with a higher rate of healing (hazard ratio, 10.73; 95% confidence interval, 4.37\u201326.38;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and sensitivity analyses supported the direction of the primary association. Because treatment was nonrandomised and clinically important baseline imbalances persisted after matching, residual confounding may substantially affect the magnitude of the estimate. These findings support prospective randomised multicentre evaluation of IVT as an adjunct to standard care.\n                  <\/jats:p>","DOI":"10.1111\/wrr.70201","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:30:10Z","timestamp":1788514210000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adjunctive Intermittent Vacuum Therapy Is Associated With Faster Healing of Chronic Lower Limb Wounds: A Single\u2010Centre Retrospective Nonrandomised Cohort Study"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7790-1347","authenticated-orcid":false,"given":"Andrea Crkvenac","family":"Gregorek","sequence":"first","affiliation":[{"name":"Department of Surgery, Division for Vascular Surgery University Hospital Center Zagreb  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3492-3837","authenticated-orcid":false,"given":"Tomislav","family":"Me\u0161trovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division for Vascular Surgery University Hospital Center Zagreb  Zagreb Croatia"},{"name":"University of Zagreb School of Medicine  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0117-7663","authenticated-orcid":false,"given":"Predrag","family":"Pavi\u0107","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division for Vascular Surgery University Hospital Center Zagreb  Zagreb Croatia"},{"name":"University of Zagreb School of Medicine  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8587-8351","authenticated-orcid":false,"given":"Damir","family":"Halu\u017ean","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division for Vascular Surgery University Hospital Center Zagreb  Zagreb Croatia"},{"name":"University of Zagreb School of Medicine  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6755-8656","authenticated-orcid":false,"given":"Josip","family":"Figl","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division for Vascular Surgery University Hospital Center Zagreb  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1981-711X","authenticated-orcid":false,"given":"Nermin","family":"Lojo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division for Vascular Surgery University Hospital Center Zagreb  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4429-1095","authenticated-orcid":false,"given":"Irena","family":"\u0160najdar","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division for Vascular Surgery University Hospital Center Zagreb  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5499-1079","authenticated-orcid":false,"given":"Ivan","family":"\u0160korak","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division for Vascular Surgery University Hospital Center Zagreb  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5874-8666","authenticated-orcid":false,"given":"Ivan","family":"Bri\u017ei\u0107","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division for Vascular Surgery University Hospital Center Zagreb  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1340-1917","authenticated-orcid":false,"given":"Majda Vrki\u0107","family":"Kirhmajer","sequence":"additional","affiliation":[{"name":"University of Zagreb School of Medicine  Zagreb Croatia"},{"name":"Department of Cardiovascular Diseases University Hospital Center Zagreb  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2019.0946"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2017.07.007"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2015.0635"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12683"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2009.18.4.41607"},{"issue":"1","key":"e_1_2_11_7_1","first-page":"5","article-title":"Chronic Wounds as a Public Health Problem","volume":"68","author":"\u0160itum M.","year":"2014","journal-title":"Acta Medica 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H.","year":"2019","journal-title":"Zhongguo Ying Yong Sheng Li Xue Za Zhi"},{"issue":"4","key":"e_1_2_11_20_1","first-page":"197","article-title":"Intermittent Negative Pressure Therapy in the Combined Treatment of Peripheral Lymphedema","volume":"48","author":"Campisi C. C.","year":"2015","journal-title":"Lymphology"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2018.1497803"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2019.02.016"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2015.10.003"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.35279\/jowm2023.24.02.sup01"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0092861512442021"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/69.1.239"},{"key":"e_1_2_11_27_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2026"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179001"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2020.10.024"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X14552096"},{"issue":"3","key":"e_1_2_11_33_1","first-page":"176","article-title":"Essentials of Hyperbaric Oxygen Therapy: 2019 Review","volume":"116","author":"Kirby J. P.","year":"2019","journal-title":"Missouri Medicine"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-0654"}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.70201","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/wrr.70201","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.70201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T09:12:42Z","timestamp":1793092362000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.70201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/wrr.70201"],"URL":"https:\/\/doi.org\/10.1111\/wrr.70201","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2025-10-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70201"}}