{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:50:12Z","timestamp":1791348612234,"version":"4.3.1"},"reference-count":54,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":35,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["955722"],"award-info":[{"award-number":["955722"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>After full\u2010thickness injuries, foetal skin regenerates, while adult skin heals with scarring. Upon injury, mesenchymal stromal cells (MSCs) produce extracellular matrix (ECM) that shapes the wound microenvironment by providing structure, regulating the availability of soluble factors and directing cell behaviour. Therefore, the ECM secreted by MSCs likely guides the healing outcome towards either scarless or scar prone healing. We analysed the ECM produced by primary human MSCs from foetal skin (hfS\u2010MSCs; regenerative\/healthy), adult dermis (hD\u2010MSCs; scarring\/healthy) and burn eschar tissue (hBE\u2010MSCs; scarring\/wounded). We first optimised ECM production across MSC populations, then quantified total ECM deposition, collagen and total protein content and analysed ECM\u2010related genes. Finally, we assessed collagen maturity in foetal versus adult skin. Standard medium containing 10\u2009\u03bcg\/mL of magnesium ascorbyl phosphate stimulated ECM deposition in all MSC populations, while minimising ECM area reduction and contraction. Total protein, collagen gene and protein expressions were higher in hfS\u2010MSC\u2010derived ECM, while ECMs derived from hBE\u2010MSCs and hD\u2010MSCs showed an increased proportion of non\u2010collagenous proteins. Collagen I:V gene ratio was decreased in hfS\u2010MSCs, while collagen I:III gene ratio was increased in hBE\u2010MSCs compared to hD\u2010MSCs. Both hfS\u2010MSCs and hBE\u2010MSCs showed increased ECM deposition and collagen insolubility. Moreover, hBE\u2010MSCs showed higher ECM contraction, as well as PLOD2 and fibronectin gene expression. Foetal skin exhibited higher immature collagen, whereas adult skin exhibited higher mature collagen. We revealed intrinsic differences in ECM amount, composition and ECM\u2010related gene expression between MSC populations and their tissues of origin, suggesting potential ECM\u2010related biomarkers underlying regeneration or repair.<\/jats:p>","DOI":"10.1111\/wrr.70202","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:56:35Z","timestamp":1791345395000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differential Extracellular Matrix Production by Mesenchymal Stromal Cells From Foetal Skin, Adult Skin and Burn Eschar"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7590-3166","authenticated-orcid":false,"given":"Madalena L. N. 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J.","family":"Krijnen","sequence":"additional","affiliation":[{"name":"Department of Pathology Amsterdam University Medical Center (AUMC)  Amsterdam the Netherlands"},{"name":"Amsterdam Cardiovascular Sciences Research Institute, AUMC, Location VUmc  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8843-1080","authenticated-orcid":false,"given":"Esther","family":"Middelkoop","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Hand Surgery AUMC, Location VUmc  Amsterdam the Netherlands"},{"name":"Tissue Function and Regeneration Amsterdam Movement Sciences Research Institute  Amsterdam the Netherlands"},{"name":"Burn Research Lab Alliance of Dutch Burn Care  Beverwijk the Netherlands"},{"name":"Alliance of Dutch Burn Care, Burn Center Red Cross Hospital  Beverwijk the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9404-9822","authenticated-orcid":false,"given":"Hans W. M.","family":"Niessen","sequence":"additional","affiliation":[{"name":"Department of Pathology Amsterdam University Medical Center (AUMC)  Amsterdam the Netherlands"},{"name":"Amsterdam Cardiovascular Sciences Research Institute, AUMC, Location VUmc  Amsterdam the Netherlands"},{"name":"Department of Cardiac Surgery AUMC, Location VUmc  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9085-6982","authenticated-orcid":false,"given":"Bouke K. H. L.","family":"Boekema","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Hand Surgery AUMC, Location VUmc  Amsterdam the Netherlands"},{"name":"Tissue Function and Regeneration Amsterdam Movement Sciences Research Institute  Amsterdam the Netherlands"},{"name":"Burn Research Lab Alliance of Dutch Burn Care  Beverwijk the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24043749","article-title":"Burns: Classification, Pathophysiology, and Treatment: A Review","volume":"24","author":"\u017bwiere\u0142\u0142o W.","year":"2023","journal-title":"International Journal of Molecular Sciences"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41572-020-0145-5","article-title":"Burn Injury","volume":"6","author":"Jeschke M. 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