{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:43:40Z","timestamp":1791924220889,"version":"4.3.4"},"reference-count":104,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":56,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Skin wound repair is a complex process involving numerous signalling pathways in various cell types. Cellular senescence (CS), described as a proliferative limit, has dual implications in this process. In acute wounds, transient cellular senescence acts as a beneficial mechanism that facilitates tissue repair through the controlled secretion of the senescence\u2010associated secretory phenotype (SASP), promoting immune cell recruitment, myofibroblast differentiation and angiogenesis. In contrast, chronic wound settings, which are frequently associated with pathological conditions including type 2 diabetes, persistent hypoxia and advanced age, promote the buildup of senescent cells and impair their immune\u2010mediated elimination. This generates a cycle of chronic inflammation through sustained SASP secretion, resulting in altered keratinocyte migration, dysfunctional fibroblast activity, abnormal extracellular matrix remodelling and healing failure. The therapeutic landscape targeting CS is rapidly evolving: senolytic approaches demonstrate efficacy in eliminating senescent cells, while senomorphic strategies effectively modulate the SASP without eliminating senescent cells. This review summarises the multifaceted involvement of CS in the healing cascade, focusing on molecular mechanisms and current senotherapeutic evidence. This analysis is crucial for developing targeted therapies that preserve the beneficial functions of CS while counteracting its pathological effects in chronic wounds and age\u2010related tissue dysfunction.<\/jats:p>","DOI":"10.1111\/wrr.70203","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:08:06Z","timestamp":1787749686000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cellular Senescence in Skin Wound Repair: Dual Roles and Senotherapeutic Interventions"],"prefix":"10.1111","volume":"34","author":[{"given":"J. A.","family":"Santiago\u2010de\u2010la\u2010Cruz","sequence":"first","affiliation":[{"name":"Direcci\u00f3n de Investigaci\u00f3n Instituto Nacional de Geriatr\u00eda (INGER)  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. J.","family":"Garc\u00eda\u2010Flores","sequence":"additional","affiliation":[{"name":"Laboratorio de Tejido Conjuntivo, Centro Nacional de Investigaci\u00f3n y Atenci\u00f3n de Quemados Instituto Nacional de Rehabilitaci\u00f3n \u201cLuis Guillermo Ibarra Ibarra\u201d  Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. N.","family":"Alonso\u2010Cruz","sequence":"additional","affiliation":[{"name":"Laboratorio de Tejido Conjuntivo, Centro Nacional de Investigaci\u00f3n y Atenci\u00f3n de Quemados Instituto Nacional de Rehabilitaci\u00f3n \u201cLuis Guillermo Ibarra Ibarra\u201d  Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2659-6864","authenticated-orcid":false,"given":"N. A.","family":"Rivero\u2010Segura","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Investigaci\u00f3n Instituto Nacional de Geriatr\u00eda (INGER)  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2178-9349","authenticated-orcid":false,"given":"A.","family":"Cabrera\u2010Wrooman","sequence":"additional","affiliation":[{"name":"Laboratorio de Tejido Conjuntivo, Centro Nacional de Investigaci\u00f3n y Atenci\u00f3n de Quemados Instituto Nacional de Rehabilitaci\u00f3n \u201cLuis Guillermo Ibarra Ibarra\u201d  Ciudad de M\u00e9xico Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16155"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.24875\/pjdv.24000028"},{"key":"e_1_2_12_4_1","volume-title":"BPR Briefs: A Digest Version of the Best Practice Recommendations for Skin Health and Wound Management 2025","author":"Wounds Canada","year":"2025"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.34115\/basrv4n2-005"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-49544-5_45"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-67175-8_2"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/life11070665"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.5958\/0974-360X.2019.00240.3"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/oso\/9780192631978.003.0010"},{"key":"e_1_2_12_11_1","first-page":"109","volume-title":"Contemporary Diabetes","author":"Pastar I.","year":"2024"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119793588.ch2"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-65381-7.00001-0"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1731791"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1515\/biol-2025-1166"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12080735"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2018.10.011"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.573032"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.31584\/psumj.2024265285"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a041221"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqab136"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/012210299x392533250818055951"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-43683-4_25"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8852759"},{"key":"e_1_2_12_25_1","first-page":"2852","article-title":"A Chronic Wound Model to Investigate Skin Cellular Senescence","volume":"15","author":"Wyles S. P.","year":"2023","journal-title":"Aging (Albany NY)"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology11121731"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(61)90192-6"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.18678\/dtfd.1500615"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-821618-7.00219-4"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-017-0667-4_8"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-022-00601-z"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.21926\/obm.geriatr.2503324"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11233732"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/geroni\/igae098.1143"},{"issue":"2024","key":"e_1_2_12_35_1","first-page":"e542","article-title":"Cellular Senescence in Cancer: Molecular Mechanisms and Therapeutic Targets","volume":"5","author":"Jin P.","year":"2020","journal-title":"MedComm"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvae079"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-025-02655-x"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.275235.121"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-023-01197-y"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-8931-7_4"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-019-0305-4"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12020348"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12030651"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2023.09.019"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-8931-7_6"},{"key":"e_1_2_12_46_1","first-page":"478","article-title":"Secretory Phenotype of the Human Endothelial Cells Associated With Replicative and Induced Aging","author":"\u0421\u0430\u0432\u0438\u0446\u043a\u0438\u0439 \u0414. \u0412.","year":"2022","journal-title":"Advances in Gerontology"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glac097"},{"key":"e_1_2_12_48_1","first-page":"2819","article-title":"The Senescence\u2010Associated Secretory Phenotype Induces Neuroendocrine Transdifferentiation","volume":"15","author":"Huna A.","year":"2023","journal-title":"Aging (Albany NY)"},{"key":"e_1_2_12_49_1","doi-asserted-by":"crossref","first-page":"737","DOI":"10.34922\/AE.2022.35.5.010","article-title":"Senescence\u2010Associated Secretory Phenotype and Inflammaging: The Role in Cardiovascular Diseases","author":"\u0421\u0430\u0432\u0438\u0446\u043a\u0438\u0439 \u0414. \u0412.","year":"2022","journal-title":"\u0423\u0441\u043f\u0435\u0445\u0438 \u0413\u0435\u0440\u043e\u043d\u0442\u043e\u043b\u043e\u0433\u0438\u0438"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2018.02.001"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2024.08.007"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26956"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-823318-4.00034-2"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1132653"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnr2.2075"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.4197\/sci.34\u20102.1"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11040672"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.18-701"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2018.1551407"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202400079"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14266"},{"key":"e_1_2_12_62_1","first-page":"2654","article-title":"Lamin\u2010B1 Is a Senescence\u2010Associated Biomarker in Clear\u2010Cell Renal Cell Carcinoma","volume":"18","author":"Radspieler M. M.","year":"2019","journal-title":"Oncology Letters"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2024.1344116"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1429716"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.04.011"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-16-7897-4_3"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-813726-0.00091-X"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1012298"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology12040499"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.4c00851"},{"key":"e_1_2_12_71_1","first-page":"167","article-title":"Granulation Tissue as a Type of Connective Tissue (Review)","author":"ITMO University","year":"2022","journal-title":"Journal of Medical and Biological Research"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.2174\/0113894501394451251128123942"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25010050"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2020.09.005"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.53331\/rar.v5i15.2463"},{"key":"e_1_2_12_76_1","volume-title":"Dentistry","author":"Thomas J. T.","year":"2024"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555\u2010025\u201001575\u2010z"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1400462"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.08.049"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.fbl2808177"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2017.0761"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.200309"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190103"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.2174\/0115733998332692241202072249"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12111659"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-022-04408-3"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI181974"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12979-020-00187-9"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9030671"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.21775\/cimb.029.037"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.14053"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.3389\/fragi.2021.714239"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16350"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1195272"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2022.0048"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1101\/2024.08.19.608670"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13676"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13671-020-00320-3"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11244094"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.593832"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42114\u2010025\u201001509\u20105"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2403-9"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1093\/stcltm\/szaf069"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-024-01740-5"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph18081176"}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.70203","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/wrr.70203","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.70203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:09:15Z","timestamp":1787807355000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.70203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":104,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/wrr.70203"],"URL":"https:\/\/doi.org\/10.1111\/wrr.70203","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70203"}}