{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:16:12Z","timestamp":1788354972762,"version":"build-2803163510"},"reference-count":104,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100020912","name":"King Faisal University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cutaneous scarring remains a major clinical challenge, often resulting in impaired function, altered tissue mechanics, and poor aesthetic outcomes. Most current anti\u2010fibrotic therapies target late\u2010stage fibrosis, when extracellular matrix deposition and myofibroblast persistence are already established, limiting regenerative benefit. We propose that scar formation is governed not by gradual accumulation of fibrotic signals but by an early mechanically regulated commitment event, that precedes overt fibrosis. We introduce the concept of a PIEZO\u2010gated mechanotransduction timing window, a finite early interval during which mechanical cues determine whether wound repair remains plastic or becomes irreversibly stabilised. In this framework, tensile load, matrix resistance, and spatial confinement generate force signals sensed by PIEZO mechanosensitive ion channels, triggering calcium\u2010dependent pathways that initiate cytoskeletal remodelling and transcriptional reprogramming. When mechanically induced states are amplified through multicellular feedback linking stromal lineage conversion with immune\u2010mediated matrix reinforcement, repair transitions from reversible intermediates to a self\u2010maintaining fibrotic configuration. Window closure occurs once contractility\u2013stiffness feedback establishes mechanical self\u2010reinforcement, rendering lineage identity persistent even if upstream signals decline. This model predicts that therapeutic efficacy depends primarily on timing: early intervention can redirect repair towards regenerative architecture, whereas delayed intervention mainly reduces fibrotic burden without restoring native tissue organisation. The mechanotransduction timing window therefore represents a measurable and potentially actionable control phase for timing\u2010guided regenerative strategies and predictive mapping of fibrotic risk.<\/jats:p>","DOI":"10.1111\/wrr.70205","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:27:43Z","timestamp":1788352063000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A\n                    <scp>PIEZO<\/scp>\n                    \u2010Gated Mechanotransduction Timing Window Governs Scar Commitment in Wound Healing"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3465-4470","authenticated-orcid":false,"given":"Rabab S.","family":"Hamad","sequence":"first","affiliation":[{"name":"Department of Biological Sciences College of Science, King Faisal University  Al\u2010Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8217-0262","authenticated-orcid":false,"given":"Mohamed A. M.","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Biology College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU)  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1506-7836","authenticated-orcid":false,"given":"Anis Ahmad","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Department of Biology College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU)  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsayed A.","family":"Elmorsy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology College of Pharmacy, Qassim University  Buraidah Saudi Arabia"},{"name":"Department of Clinical Pharmacology Faculty of Medicine, Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha M.","family":"Amer","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Histology College of Medicine, Qassim University  Buraidah Saudi Arabia"},{"name":"Department of Anatomy and Embryology Faculty of Medicine, Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed R.","family":"Abdel\u2010Hamed","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Histology College of Medicine, Qassim University  Buraidah Saudi Arabia"},{"name":"Department of Anatomy and Embryology Faculty of Medicine, Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5060-0790","authenticated-orcid":false,"given":"Attalla F.","family":"El\u2010kott","sequence":"additional","affiliation":[{"name":"Department of Biology College of Science, King Khalid University  Abha Saudi Arabia"},{"name":"Department of Zoology Faculty of Science, Damanhour University  Damanhour Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed","family":"Eltantawy","sequence":"additional","affiliation":[{"name":"Department of Biology Program of Preparatory Year, Batterjee Medical College  Aseer Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed A.","family":"AlShehri","sequence":"additional","affiliation":[{"name":"Department of Biology College of Science, King Khalid University  Abha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan","family":"Eissa","sequence":"additional","affiliation":[{"name":"Department of Pharmacology College of Medicine, University of Bisha  Bisha Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alshaimaa A.","family":"Farrag","sequence":"additional","affiliation":[{"name":"Department of Histology and Cell Biology College of Medicine, Assiut University  Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameh","family":"Saber","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Faculty of Pharmacy, Delta University for Science and Technology  Gamasa Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"crossref","DOI":"10.1111\/wrr.70094","article-title":"Early Patient\u2010Reported Outcomes as Predictors of Long\u2010Term Scar Satisfaction: An Exploratory Cohort Study","volume":"33","author":"Nguyen A.","year":"2025","journal-title":"Wound Repair and Regeneration"},{"key":"e_1_2_15_3_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107245","article-title":"The Current Landscape of Antifibrotic Therapy Across Different Organs: A Systematic Approach","volume":"205","author":"Fuster\u2010Mart\u00ednez I.","year":"2024","journal-title":"Pharmacological Research"},{"key":"e_1_2_15_4_1","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/j.stem.2025.10.002","article-title":"Tissue Regeneration: Unraveling Strategies for Resolving Pathological Fibrosis","volume":"32","author":"Li J.","year":"2025","journal-title":"Cell Stem Cell"},{"key":"e_1_2_15_5_1","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adt6387","article-title":"Inhibiting Mechanotransduction Prevents Scarring and Yields Regeneration in a Large Animal Model","volume":"17","author":"Mascharak S.","year":"2025","journal-title":"Science Translational Medicine"},{"key":"e_1_2_15_6_1","doi-asserted-by":"crossref","DOI":"10.3390\/life14030377","article-title":"Roles of Mechanosensitive Channel Piezo1 in Wound Healing and Scar Formation","volume":"14","author":"Rennekampff H. 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