{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T10:36:48Z","timestamp":1793011008497,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP24K12821"],"award-info":[{"award-number":["JP24K12821"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23H05483"],"award-info":[{"award-number":["23H05483"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Deep burn injuries in mammals typically heal with fibrosis and scar formation. Although the Japanese fire\u2010bellied newt (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Cynops pyrrhogaster<\/jats:italic>\n                    <\/jats:styled-content>\n                    ) exhibits scarless skin regeneration after injury, whether this capacity is maintained after third\u2010degree burn remains unclear. A third\u2010degree burn model was established in adult newts, and the regenerative process was analysed over 1\u2009year using macroscopic, histological, ultrastructural and molecular approaches. Blood cell dynamics and proliferative cells were evaluated by Wright\u2013Giemsa staining and PCNA immunohistochemistry. Burn wounds were completely re\u2010epithelialised by post\u2010burn day (PBD) 8 despite persistence of damaged tissue. The wound subsequently underwent progressive tissue remodelling and closely resembled normal skin macroscopically by PBD 365 without evidence of contracture. Histological and ultrastructural analyses demonstrated restoration of organised dermal collagen architecture and muscle sarcomere structures without fibrotic scar formation. Erythrocytes transiently accumulated within damaged tissues and peaked on PBD 12, whereas neutrophils peaked earlier and declined after re\u2010epithelialisation. PCNA\u2010positive proliferative cells in the dermis and subcutaneous tissue peaked on PBD 30. Semi\u2010quantitative RT\u2010PCR suggested temporal changes in inflammatory marker expression during the regenerative process. Adult newts achieve scarless regeneration following third\u2010degree burns. These findings establish a useful experimental model and provide a comprehensive characterisation of scarless regeneration following third\u2010degree burns, providing a foundation for future mechanistic studies.\n                  <\/jats:p>","DOI":"10.1111\/wrr.70208","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T04:21:50Z","timestamp":1788754910000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Scarless Regeneration Following Third\u2010Degree Burns in the Japanese Fire\u2010Bellied Newt (\n                    <scp>\n                      <i>Cynops pyrrhogaster<\/i>\n                    <\/scp>\n                    )"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3636-0393","authenticated-orcid":false,"given":"Ikkei","family":"Takashimizu","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8912-934X","authenticated-orcid":false,"given":"Kengo","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fubito","family":"Toyama","sequence":"additional","affiliation":[{"name":"Graduate School of Engineering Utsunomiya University  Utsunomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7767-2150","authenticated-orcid":false,"given":"Chikafumi","family":"Chiba","sequence":"additional","affiliation":[{"name":"Faculty of Life and Environmental Sciences University of Tsukuba  Tsukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2218-9601","authenticated-orcid":false,"given":"Shunsuke","family":"Yuzuriha","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18004016413"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkad061"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0305-4179(95)00164-6"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(79)90252-3"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2009.00638.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2009.00533.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2013.0485"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200208000-00031"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18030606"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-014-1612-5"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0000000000000167"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12518"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12562"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1389"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep06043"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11069"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep33761"},{"key":"e_1_2_11_19_1","first-page":"1892","article-title":"Skin Wound Healing of the Adult Newt, \n                     Cynops pyrrhogaster\n                  ; A Unique Re\u2010Epithelialization and Scarless Model","volume":"9","author":"Ishii T.","year":"2021","journal-title":"Biomedicine"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07039"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009337"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.25251\/skin.6.5.3"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1034420"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00254.2023"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2011.334"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2215"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2873"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathmechdis-012419-032847"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2012.01146.x"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0145-5"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam7928"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-25867-x"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.02.015"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1300290110"}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.70208","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/wrr.70208","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.70208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T10:27:33Z","timestamp":1793010453000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.70208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/wrr.70208"],"URL":"https:\/\/doi.org\/10.1111\/wrr.70208","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70208"}}