{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T05:10:51Z","timestamp":1788757851449,"version":"build-2803163510"},"reference-count":87,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Chronic and complex wounds are a major burden worldwide, and a considerable number remain unresponsive to traditional therapy. Cord blood\u2010derived platelet gel (CBPG) is a novel allogeneic wound therapy providing a fibrin\u2010based scaffold enriched with neonatal platelet\u2010derived growth factors, including high concentrations of VEGF, HGF and FGF, directly into the wound bed, without the need for blood collection from the patient. This narrative review provides an overview of the biological features of CBPG, discusses clinical evidence across different wound indications, and assesses ethical, regulatory, and translational issues important to its development. CBPG has been studied in clinical trials in recessive dystrophic epidermolysis bullosa, cutaneous and oral chronic graft versus host disease after allogeneic haematopoietic stem cell transplantation, partial thickness burns, neonatal pressure injuries and diabetic foot ulcers. Across these conditions, CBPG has shown a consistent safety profile and promising signals of benefit, but evidence is restricted by small sample sizes, diverse methods and short follow\u2010up. CBPG offers a biologically rational alternative to complex wound management in fragile patient populations. To move toward validated clinical application, manufacturing standardisation, regulatory classification, multicentre randomised trials with embedded health\u2010economic endpoints, and transparent governance of cord blood allocation are needed.<\/jats:p>","DOI":"10.1111\/wrr.70209","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T04:20:40Z","timestamp":1788754840000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cord Blood\u2010Derived Platelet Gel in Wound Healing: From Biological Rationale to Clinical Application"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2629-1832","authenticated-orcid":false,"given":"Amirali","family":"Kalantari","sequence":"first","affiliation":[{"name":"Pediatric Cell and Gene Therapy Research Center, Gene, Cell &amp; Tissue Research Institute Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9658-6354","authenticated-orcid":false,"given":"Zahra","family":"Karimizadeh","sequence":"additional","affiliation":[{"name":"Pediatric Cell and Gene Therapy Research Center, Gene, Cell &amp; Tissue Research Institute Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atoosa","family":"Eftekhar","sequence":"additional","affiliation":[{"name":"Pediatric Cell and Gene Therapy Research Center, Gene, Cell &amp; Tissue Research Institute Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashin","family":"Mohseni","sequence":"additional","affiliation":[{"name":"Pediatric Cell and Gene Therapy Research Center, Gene, Cell &amp; Tissue Research Institute Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arghavan","family":"Tajalli","sequence":"additional","affiliation":[{"name":"Pediatric Cell and Gene Therapy Research Center, Gene, Cell &amp; Tissue Research Institute Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4835-3751","authenticated-orcid":false,"given":"Mina","family":"Mokaram Doost Delkhah","sequence":"additional","affiliation":[{"name":"Pediatric Cell and Gene Therapy Research Center, Gene, Cell &amp; Tissue Research Institute Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Behfar","sequence":"additional","affiliation":[{"name":"Pediatric Cell and Gene Therapy Research Center, Gene, Cell &amp; Tissue Research Institute Tehran University of Medical Sciences  Tehran Iran"},{"name":"Children's Medical Center, Pediatric Center of Excellence, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8935-079X","authenticated-orcid":false,"given":"Amir Ali","family":"Hamidieh","sequence":"additional","affiliation":[{"name":"Pediatric Cell and Gene Therapy Research Center, Gene, Cell &amp; Tissue Research Institute Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,6]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.annepidem.2018.10.005","article-title":"Prevalence of Chronic Wounds in the General Population: Systematic Review and Meta\u2010Analysis of Observational Studies","volume":"29","author":"Martinengo L.","year":"2019","journal-title":"Annals of Epidemiology"},{"issue":"4","key":"e_1_2_16_3_1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1001\/jamadermatol.2023.6277","article-title":"Patient\u2010Reported Outcomes and Mortality in Cutaneous Chronic Graft\u2010Vs\u2010Host Disease","volume":"160","author":"Baumrin E.","year":"2024","journal-title":"JAMA Dermatology"},{"issue":"1","key":"e_1_2_16_4_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41572-022-00377-3","article-title":"Chronic Wounds","volume":"8","author":"Falanga V.","year":"2022","journal-title":"Nature Reviews Disease Primers"},{"issue":"1","key":"e_1_2_16_5_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jval.2017.07.007","article-title":"An Economic Evaluation of the Impact, Cost, and Medicare Policy Implications of Chronic Nonhealing Wounds","volume":"21","author":"Nussbaum S. R.","year":"2018","journal-title":"Value in Health"},{"issue":"1","key":"e_1_2_16_6_1","first-page":"1","article-title":"Chronic Wounds and Dressings: An Overview of Management and Effectiveness","volume":"60","author":"Sengul T.","year":"2025","journal-title":"Nursing Clinics"},{"issue":"5","key":"e_1_2_16_7_1","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1021\/acsabm.4c00138","article-title":"Advanced Dressings for Chronic Wound Management","volume":"7","author":"Mishra A.","year":"2024","journal-title":"ACS Applied Bio Materials"},{"issue":"3","key":"e_1_2_16_8_1","first-page":"208","article-title":"Cord Blood\u2010Derived Platelet Concentrates as Starting Material for New Therapeutic Blood Components Prepared in a Public Cord Blood Bank: From Product Development to Clinical Application","volume":"18","author":"Samarkanova D.","year":"2020","journal-title":"Blood Transfusion"},{"issue":"1","key":"e_1_2_16_9_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.transci.2019.102716","article-title":"Platelet\u2010Derived Bio\u2010Products: Classification Update, Applications, Concerns and New Perspectives","volume":"59","author":"Acebes\u2010Huerta A.","year":"2020","journal-title":"Transfusion and Apheresis Science"},{"issue":"7","key":"e_1_2_16_10_1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.3109\/09537104.2010.514626","article-title":"Platelet Gel From Cord Blood: A Novel Tool for Tissue Engineering","volume":"21","author":"Parazzi V.","year":"2010","journal-title":"Platelets"},{"issue":"8","key":"e_1_2_16_11_1","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s43465-024-01212-5","article-title":"Decoding the Decade: Exploring the Efficacy of Platelet\u2010Rich Plasma (PRP) in Complex Wound Management\u2013A Comprehensive Study","volume":"58","author":"Shrivastava S.","year":"2024","journal-title":"Indian Journal of Orthopaedics"},{"issue":"3","key":"e_1_2_16_12_1","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3390\/jpm13030430","article-title":"The Efficiency and Safety of Platelet\u2010Rich Plasma Dressing in the Treatment of Chronic Wounds: A Systematic Review and Meta\u2010Analysis of Randomized Controlled Trials","volume":"13","author":"Li S.","year":"2023","journal-title":"Journal of Personalized Medicine"},{"issue":"1","key":"e_1_2_16_13_1","article-title":"Variability in Platelet\u2010Rich Plasma Preparations Used in Regenerative Medicine: A Comparative Analysis","volume":"2022","author":"Tey R. 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