{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:50:23Z","timestamp":1791348623264,"version":"4.3.1"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":35,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571908"],"award-info":[{"award-number":["81571908"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871565"],"award-info":[{"award-number":["81871565"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103706"],"award-info":[{"award-number":["82103706"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Surgical wound dehiscence (SWD) is a serious postoperative complication associated with significant morbidity, mortality and healthcare costs. Traditional management, including negative pressure wound therapy (NPWT), relies on secondary intention healing, which can be prolonged. This study evaluates a strategy of aggressive surgical debridement followed by primary wound closure (ASDC) to convert surgical wounds to primary intention healing. In this retrospective cohort study, we compared outcomes between ASDC and NPWT in 106 SWD patients (2013\u20132023). The ASDC group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200962) underwent radical debridement and early closure, while the NPWT group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200944) received standard debridement and NPWT until complete epithelialization. Healing time, hospital stay, costs and complications were analyzed. Non\u2010parametric tests and Kaplan\u2013Meier analysis with log\u2010rank test were used for comparisons. The ASDC group had a significantly shorter median healing time (21.0 vs. 47.5\u2009days,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and median hospital stay (14.0 vs. 19.0\u2009days,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004). Total treatment costs were lower in the ASDC group (36,897\u2009\u00b1\u200914,188 vs. 57,457\u2009\u00b1\u200928,791 RMB,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Complication rates (infection, bleeding, reoperation) showed no statistically significant difference between groups. Sensitivity analysis of patients treated during the overlapping protocol period (2015\u20132017) yielded consistent results. In this retrospective analysis, ASDC was associated with significantly accelerated wound healing, shorter hospitalization and lower costs compared to NPWT for SWD management, without an increase in detected complications. This suggests ASDC may be an efficient alternative strategy, though prospective studies are needed to control for selection bias and confirm these findings.\n                  <\/jats:p>","DOI":"10.1111\/wrr.70218","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:58:27Z","timestamp":1791345507000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aggressive Surgical Debridement With Primary Closure for Surgical Wound Dehiscence: A Retrospective Cohort Study Comparing Healing Outcomes to Negative Pressure Wound Therapy"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4993-8385","authenticated-orcid":false,"given":"Xiaoling","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4222-9810","authenticated-orcid":false,"given":"Haibo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongming","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0026-0676","authenticated-orcid":false,"given":"Zhicheng","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Burn and Wound Repair The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongye","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchao","family":"Rong","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8869-8372","authenticated-orcid":false,"given":"Zirui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8983-7311","authenticated-orcid":false,"given":"Lei","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5859-8250","authenticated-orcid":false,"given":"Bing","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4653-3489","authenticated-orcid":false,"given":"Rong","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"issue":"3","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.12968\/jowc.2018.27.3.119","article-title":"Surgical Wound Dehiscence: A Conceptual Framework for Patient Assessment","volume":"27","author":"Sandy\u2010Hodgetts K.","year":"2018","journal-title":"Journal of Wound Care"},{"issue":"8","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1001\/jamasurg.2017.0904","article-title":"Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017","volume":"152","author":"Berr\u00edos\u2010Torres S. I.","year":"2017","journal-title":"JAMA Surgery"},{"issue":"11","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1002\/bjs.7275","article-title":"Surgical\u2010Site Infection","volume":"97","author":"Leaper D. J.","year":"2010","journal-title":"British Journal of Surgery"},{"issue":"4","key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1089\/sur.2012.131","article-title":"Adherence to Surgical Care Improvement Project Measures and Post\u2010Operative Surgical Site Infections","volume":"13","author":"Awad S. S.","year":"2012","journal-title":"Surgical Infections"},{"issue":"1","key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jval.2017.07.007","article-title":"An Economic Evaluation of the Impact, Cost, and Medicare Policy Implications of Chronic Nonhealing Wounds","volume":"21","author":"Nussbaum S. R.","year":"2018","journal-title":"Value in Health"},{"issue":"6","key":"e_1_2_11_7_1","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD011278.pub2","article-title":"Negative Pressure Wound Therapy for Treating Surgical Wounds Healing by Secondary Intention","volume":"2015","author":"Dumville J. C.","year":"2015","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1749-8090-7-67","article-title":"Treatment Outcomes of Postoperative Mediastinitis in Cardiac Surgery; Negative Pressure Wound Therapy Versus Conventional Treatment","volume":"7","author":"Deniz H.","year":"2012","journal-title":"Journal of Cardiothoracic Surgery"},{"issue":"12","key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"e022591","DOI":"10.1136\/bmjopen-2018-022591","article-title":"Costs and Outcomes in Evaluating Management of Unhealed Surgical Wounds in the Community in Clinical Practice in the UK: A Cohort Study","volume":"8","author":"Guest J. F.","year":"2018","journal-title":"BMJ Open"},{"issue":"1","key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jvs.2013.06.073","article-title":"Vacuum\u2010Assisted Wound Closure Versus Alginate for the Treatment of Deep Perivascular Wound Infections in the Groin After Vascular Surgery","volume":"59","author":"Monsen C.","year":"2014","journal-title":"Journal of Vascular Surgery"},{"issue":"12","key":"e_1_2_11_11_1","first-page":"1406","article-title":"The Use of Negative\u2010Pressure Wound Therapy in Pilonidal Sinus Disease","volume":"57","author":"Biter L. U.","year":"2014","journal-title":"Diseases of the Colon & Rectum"},{"issue":"4","key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.1600-051X.1995.tb00149.x","article-title":"Increased Collagen Degradation by Experimentally\u2010Induced Granulation Tissue Inoculated With Bacteria","volume":"22","author":"Asman B.","year":"1995","journal-title":"Journal of Clinical Periodontology"},{"issue":"1","key":"e_1_2_11_13_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s41232-023-00302-5","article-title":"Preadipocytes in Human Granulation Tissue: Role in Wound Healing and Response to Macrophage Polarization","volume":"43","author":"Rauchenwald T.","year":"2023","journal-title":"Inflammation and Regeneration"},{"issue":"7","key":"e_1_2_11_14_1","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1111\/iwj.13794","article-title":"Effect of Wound Irrigation on the Prevention of Surgical Site Infections: A Meta\u2010Analysis","volume":"19","author":"Fu C.","year":"2022","journal-title":"International Wound Journal"}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.70218","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/wrr.70218","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.70218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:58:31Z","timestamp":1791345511000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.70218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/wrr.70218"],"URL":"https:\/\/doi.org\/10.1111\/wrr.70218","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70218"}}