{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:40:27Z","timestamp":1792431627186,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":48,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS\u20102025\u201000523018"],"award-info":[{"award-number":["RS\u20102025\u201000523018"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002560","name":"Soonchunhyang University","doi-asserted-by":"publisher","award":["SCHCA 2026\u201004\u2010044"],"award-info":[{"award-number":["SCHCA 2026\u201004\u2010044"]}],"id":[{"id":"10.13039\/501100002560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic wound healing depends on local wound\u2010edge perfusion, which is not fully characterised by conventional vascular assessments. We evaluated whether quantitative periwound ring enhancement on indocyanine green angiography could predict 12\u2010week wound healing. This retrospective cohort study included 71 patients with diabetic foot ulcers or pressure sores who underwent baseline indocyanine green angiography. Relative fluorescence intensity, time to peak, perfusion slope and ring continuity were quantified and integrated into an exploratory 0\u20138\u2010point Perfusion Success Index. Forty\u2010two patients achieved complete healing within 12\u2009weeks and 29 did not. Healers showed higher relative fluorescence intensity, shorter time to peak, steeper perfusion slope, greater ring continuity and a higher Perfusion Success Index than non\u2010healers (5.83\u2009\u00b1\u20091.45 vs. 3.24\u2009\u00b1\u20091.38,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). The Perfusion Success Index demonstrated the highest overall discrimination for 12\u2010week healing (area under the curve, 0.894; 95% confidence interval, 0.823\u20130.965); a cut\u2010off of \u2265\u20095 yielded 83.3% sensitivity and 82.8% specificity. A clinical model including wound type, wound area, wound depth, infection and serum albumin had an area under the curve of 0.777, which increased to 0.908 after addition of the Perfusion Success Index (absolute increase in area under the curve, 0.131;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.012). After bootstrap internal validation, the clinical\u2010plus\u2010index model retained favourable discrimination with an optimism\u2010corrected area under the curve of approximately 0.87. Quantitative periwound ring enhancement on indocyanine green angiography may provide complementary prognostic information regarding wound\u2010edge healing potential beyond conventional clinical assessment.\n                  <\/jats:p>","DOI":"10.1111\/wrr.70220","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:11:03Z","timestamp":1792429863000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Periwound Ring Enhancement on Indocyanine Green Angiography as a Prognostic Imaging Biomarker for Chronic Wound Healing"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2494-0991","authenticated-orcid":false,"given":"Ha Jong","family":"Nam","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Soonchunhyang University Gumi Hospital  Gumi Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Soonchunhyang University Cheonan Hospital  Cheonan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2308-6308","authenticated-orcid":false,"given":"Young Hyun","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Soonchunhyang University Cheonan Hospital  Cheonan Korea"},{"name":"Department of Physiology College of Medicine, Soonchunhyang University  Cheonan Republic of Korea"},{"name":"Institute for Molecular Metabolism Innovation Soonchunhyang University  Asan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0752-0389","authenticated-orcid":false,"given":"Hwan Jun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Soonchunhyang University Cheonan Hospital  Cheonan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1056\/NEJMra1615439","article-title":"Diabetic Foot Ulcers and Their Recurrence","volume":"376","author":"Armstrong D. G.","year":"2017","journal-title":"New England Journal of Medicine"},{"key":"e_1_2_14_3_1","volume-title":"Prevention and Treatment of Pressure Ulcers\/Injuries: Clinical Practice Guideline. The International Guideline","author":"European Pressure Ulcer Advisory Panel, National Pressure Injury Advisory Panel, Pan Pacific Pressure Injury Alliance","year":"2019"},{"key":"e_1_2_14_4_1","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1152\/physrev.00067.2017","article-title":"Wound Healing: A Cellular Perspective","volume":"99","author":"Rodrigues M.","year":"2019","journal-title":"Physiological Reviews"},{"key":"e_1_2_14_5_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1046\/j.1087-0024.2000.00014.x","article-title":"Angiogenesis in Wound Healing","volume":"5","author":"Tonnesen M. G.","year":"2000","journal-title":"Journal of Investigative Dermatology. Symposium Proceedings"},{"key":"e_1_2_14_6_1","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.3657","article-title":"Practical Guidelines on the Prevention and Management of Diabetes\u2010Related Foot Disease (IWGDF 2023 Update)","volume":"40","author":"Schaper N. C.","year":"2024","journal-title":"Diabetes\/Metabolism Research and Reviews"},{"key":"e_1_2_14_7_1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.ejvs.2019.05.006","article-title":"Global Vascular Guidelines on the Management of Chronic Limb\u2010Threatening Ischemia","volume":"58","author":"Conte M. S.","year":"2019","journal-title":"European Journal of Vascular and Endovascular Surgery"},{"key":"e_1_2_14_8_1","doi-asserted-by":"crossref","DOI":"10.1111\/iwj.14431","article-title":"The Correlation Between Transcutaneous Oxygen Pressure (TcPO2) and Forward\u2010Looking Infrared (FLIR) Thermography in the Evaluation of Lower Extremity Perfusion According to Angiosome","volume":"21","author":"Nam H. J.","year":"2024","journal-title":"International Wound Journal"},{"key":"e_1_2_14_9_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0039-6257(00)00123-5","article-title":"Fluorescence Properties and Metabolic Features of Indocyanine Green as Related to Angiography","volume":"45","author":"Desmettre T.","year":"2000","journal-title":"Survey of Ophthalmology"},{"key":"e_1_2_14_10_1","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/940585","article-title":"A Review of Indocyanine Green Fluorescent Imaging in Surgery","volume":"2012","author":"Alander J. T.","year":"2012","journal-title":"International Journal of Biomedical Imaging"},{"key":"e_1_2_14_11_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.22467\/jwmr.2023.02383","article-title":"Utility of Indocyanine Green Fluorescence Imaging in Wound Assessment","volume":"19","author":"Cha H. G.","year":"2023","journal-title":"Journal of Wound Management and Research"},{"key":"e_1_2_14_12_1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.avsg.2018.02.021","article-title":"Indocyanine Green Angiography to Prognosticate Healing of Foot Ulcer in Critical Limb Ischemia: A Novel Technique","volume":"51","author":"Patel H. M.","year":"2018","journal-title":"Annals of Vascular Surgery"},{"key":"e_1_2_14_13_1","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.ejvs.2013.07.016","article-title":"Quantitative Evaluation of the Outcomes of Revascularization Procedures for Peripheral Arterial Disease Using Indocyanine Green Angiography","volume":"46","author":"Igari K.","year":"2013","journal-title":"European Journal of Vascular and Endovascular Surgery"},{"key":"e_1_2_14_14_1","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.jvs.2012.10.113","article-title":"Early Quantitative Evaluation of Indocyanine Green Angiography in Patients With Critical Limb Ischemia","volume":"57","author":"Braun J. D.","year":"2013","journal-title":"Journal of Vascular Surgery"},{"key":"e_1_2_14_15_1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.avsg.2016.07.084","article-title":"Microcirculation Evaluated by Intraoperative Fluorescence Angiography After Tibial Bypass Surgery","volume":"40","author":"Rother U.","year":"2017","journal-title":"Annals of Vascular Surgery"},{"key":"e_1_2_14_16_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/PRS.0000000000007482","article-title":"Hyperbaric Oxygen Therapy in Management of Diabetic Foot Ulcers: Indocyanine Green Angiography May Be Used as a Biomarker to Analyze Perfusion and Predict Response to Treatment","volume":"147","author":"Hajhosseini B.","year":"2021","journal-title":"Plastic and Reconstructive Surgery"},{"key":"e_1_2_14_17_1","doi-asserted-by":"crossref","DOI":"10.1111\/iwj.70723","article-title":"Assessment of Hard\u2010To\u2010Heal Lower Leg Wounds With Near\u2010Infrared Fluorescent Imaging: A Pilot Cohort Study","volume":"22","author":"Clifford K. A.","year":"2025","journal-title":"International Wound Journal"},{"key":"e_1_2_14_18_1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.avsg.2021.04.030","article-title":"Assessment of Tissue Viability Following Amputation Surgery Using Near\u2010Infrared Fluorescence Imaging With Indocyanine Green","volume":"78","author":"Hoven P.","year":"2022","journal-title":"Annals of Vascular Surgery"},{"key":"e_1_2_14_19_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jcm.2016.02.012","article-title":"A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research","volume":"15","author":"Koo T. K.","year":"2016","journal-title":"Journal of Chiropractic Medicine"},{"key":"e_1_2_14_20_1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3","article-title":"Index for Rating Diagnostic Tests","volume":"3","author":"Youden W. J.","year":"1950","journal-title":"Cancer"},{"key":"e_1_2_14_21_1","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1097\/TA.0000000000002179","article-title":"Indocyanine Green Dye Angiography as an Adjunct to Assess Indeterminate Burn Wounds: A Prospective, Multicentered, Triple\u2010Blinded Study","volume":"86","author":"Wongkietkachorn A.","year":"2019","journal-title":"Journal of Trauma and Acute Care Surgery"},{"key":"e_1_2_14_22_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1080\/23320885.2018.1481410","article-title":"Potential of Near\u2010Infrared Fluorescence Image\u2010Guided Debridement in Trauma Surgery","volume":"5","author":"Pruimboom T.","year":"2018","journal-title":"Case Reports in Plastic Surgery and Hand Surgery"},{"key":"e_1_2_14_23_1","doi-asserted-by":"crossref","DOI":"10.3390\/diagnostics15172221","article-title":"New Application for the Early Detection of Wound Infections Using a Near\u2010Infrared Fluorescence Device and Forward\u2010Looking Thermal Camera","volume":"15","author":"Nam H. J.","year":"2025","journal-title":"Diagnostics"}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.70220","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/wrr.70220","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.70220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:11:07Z","timestamp":1792429867000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.70220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/wrr.70220"],"URL":"https:\/\/doi.org\/10.1111\/wrr.70220","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-08-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70220"}}