{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:52:08Z","timestamp":1791139928181,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pyoderma gangrenosum (PG) is a rare, painful ulcerative dermatosis associated with significant functional impairment. Complete w closure is the standard endpoint in wound clinical trials, including PG, but clinically meaningful improvement may occur before total epithelization is achieved. No disease\u2010specific minimal important difference exists for patient\u2010reported physical function in PG. We evaluated whether partial healing is associated with differences in physical function and estimated such a threshold using the Skindex\u2010Mini. This retrospective cohort study included adults with PG receiving dermatologic care at a single academic referral centre between August 2024 and November 2025. Clinical data and patient\u2010reported outcome measures were obtained from a prospectively maintained PG registry and electronic health records. Healing stage at each visit was categorized as healed, partially healed (\u2265\u200950% reduction in ulcer area) or not healed, and Skindex\u2010Mini Physical Function scores (0\u2013100 scale, higher scores indicating worse function) were compared using linear mixed\u2010effects models. The cohort included 80 adults with PG contributing 385 clinical encounters. Physical function scores differed significantly across healing stages (\n                    <jats:italic>\u03c7<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200939.0;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Compared with unhealed patients, partially healed patients reported better physical function (approximately 17 points lower) and were closer to fully healed patients. A 1\u2010point improvement in patient global assessment corresponded to an adjusted 20.8\u2010point improvement in physical function (95% CI, 14.5\u201327.2;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), consistent with distribution\u2010based estimates. Partially healed patients reported substantially better physical function than unhealed patients, supporting incorporation of patient\u2010reported physical function and intermediate healing states alongside complete wound closure in PG outcome assessment.\n                  <\/jats:p>","DOI":"10.1111\/wrr.70222","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:11:35Z","timestamp":1791137495000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Partial Healing and Physical Function in Pyoderma Gangrenosum: A Framework for Wound Endpoints"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0140-7237","authenticated-orcid":false,"given":"Jaclyn","family":"Roland\u2010McGowan","sequence":"first","affiliation":[{"name":"Department of Dermatology Oregon Health and Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8436-5626","authenticated-orcid":false,"given":"Jordan","family":"Gillespie","sequence":"additional","affiliation":[{"name":"Department of Dermatology Oregon Health and Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria E.","family":"Orfaly","sequence":"additional","affiliation":[{"name":"Department of Dermatology Oregon Health and Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7749-7217","authenticated-orcid":false,"given":"Emile","family":"Latour","sequence":"additional","affiliation":[{"name":"Biostatistics Shared Resource, Knight Cancer Institute Oregon Health and Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8782-4971","authenticated-orcid":false,"given":"Katelyn","family":"Downey","sequence":"additional","affiliation":[{"name":"Department of Dermatology Oregon Health and Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard H.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Larner College of Medicine University of Vermont  Burlington Vermont USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5028-9269","authenticated-orcid":false,"given":"Alex G.","family":"Ortega\u2010Loayza","sequence":"additional","affiliation":[{"name":"Department of Dermatology Oregon Health and Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.25259\/IJDVL_968_20"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0141076814534407"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASW.0000755920.76330.21"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2023.3115"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12939"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.130"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2022.5437"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2024.12.023"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12707"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.21.01539"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.18472"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/21621918251359554"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2024.10.015"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljaf381"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16401"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.05.040"},{"key":"e_1_2_13_18_1","unstructured":"The R Foundation \u201cR: The R Project for Statistical Computing \u201dcited January 24 2025 https:\/\/www.r\u2010project.org\/."},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12484"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/17482631.2022.2054080"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/CWCMR.S124917"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524\u2010475x.2010.00583.x"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/12034754211051239"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000820"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475420930222"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2025.05.1113"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346\u20108138.15533"},{"key":"e_1_2_13_28_1","unstructured":"InflaRx GmbH \u201cA Randomized Double\u2010Blind Placebo\u2010Controlled Multicenter Adaptive Phase III Trial to Investigate Efficacy and Safety of Vilobelimab in the Treatment of Ulcerative Pyoderma Gangrenosum \u201dClinical Trial Registration No. NCT05964413 November 2025 https:\/\/clinicaltrials.gov\/study\/NCT05964413."}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.70222","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/wrr.70222","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.70222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:11:38Z","timestamp":1791137498000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.70222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/wrr.70222"],"URL":"https:\/\/doi.org\/10.1111\/wrr.70222","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70222"}}