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Currently, self\u2010management interventions based on e\u2010health have been used to improve\n                      <jats:styled-content style=\"fixed-case\">QoL<\/jats:styled-content>\n                      among cancer patients, but the overall effects remain inconsistent.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the impact of self\u2010management interventions based on e\u2010health on the QoL of cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Studies were retrieved from six databases up to November 6, 2024. The methodological quality assessment was performed via ROB 2. Data synthesis and subgroup analyses were performed in Review Manager 5.3. Meta\u2010regression was conducted using Stata 15.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty RCTs were included. The results of meta\u2010analysis revealed self\u2010management interventions based on e\u2010health significantly improved QoL (SMD\u2009=\u20090.18, 95% CI: 0.08 to 0.28,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Subgroup analyses showed that long\u2010term, mixed\u2010mode, theory\u2010supported, or facilitator\u2010supervised interventions were more effective, with greater improvements in QoL observed among patients with breast cancer than among other types.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Linking Evidence to Action<\/jats:title>\n                    <jats:p>Self\u2010management interventions based on e\u2010health were valuable supplements for enhancing the QoL of cancer patients. Intervention duration, delivery modes, cancer types, theoretical frameworks, and facilitators' involvement should be considered in the design of future interventions. However, additional high\u2010quality studies are needed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>The protocol was registered on PROSPERO (Registration number: CRD420251017709)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/wvn.70154","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:52:38Z","timestamp":1780635158000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Efficacy of Self\u2010Management Interventions Based on E\u2010Health in Quality of Life in Patients With Cancer: A Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1367-1815","authenticated-orcid":false,"given":"Jialin","family":"Zhang","sequence":"first","affiliation":[{"name":"West China School of Nursing West China Hospital, Sichuan University  Chengdu Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8688-7903","authenticated-orcid":false,"given":"Shu","family":"Zhang","sequence":"additional","affiliation":[{"name":"West China School of Nursing West China Hospital, Sichuan University  Chengdu Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linna","family":"Li","sequence":"additional","affiliation":[{"name":"West China School of Nursing West China Hospital, Sichuan University  Chengdu Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9895-2754","authenticated-orcid":false,"given":"Liyang","family":"Duan","sequence":"additional","affiliation":[{"name":"West China School of Nursing West China Hospital, Sichuan University  Chengdu Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Hu","sequence":"additional","affiliation":[{"name":"West China School of Nursing West China Hospital, Sichuan University  Chengdu Sichuan People's Republic of China"},{"name":"Tianfu Jincheng Laboratory City of Future Medicine  Chengdu Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30815"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a1864"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2017.07.009"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4040\/jkan.21028"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2019.010"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-021-06513-1"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010022\u201007039\u2010w"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913\u2010019\u20104106\u20101"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2016.68.8788"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/wvn.70048"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.5246"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-018-0902-7"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3205\/psm000074"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0220116"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.2196\/28852"},{"issue":"7","key":"e_1_2_10_19_1","article-title":"Revolutionizing Healthcare: How Telemedicine Is Improving Patient Outcomes and Expanding Access to Care","volume":"16","author":"Ezeamii V. 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