{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T05:17:01Z","timestamp":1788153421082,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["sigmapubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Worldviews Ev Based Nurs"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>With antiretroviral therapy, HIV has become a manageable chronic condition, shifting focus to improving health\u2010related quality of life (HRQoL). Non\u2010pharmacological interventions offer distinct advantages for optimizing long\u2010term health outcomes in people living with HIV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify optimal non\u2010pharmacological interventions for improving overall HRQoL and its domains (physical, psychological, social, environmental, independence, spiritual).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ten databases (Embase, MEDLINE, Web of Science Core Collection, CINAHL, PsycINFO, CENTRAL, CBM, CNKI, VIP Information, Wanfang Data) were searched from inception to August 2025. Bayesian network meta\u2010analyzes were performed for direct and indirect comparisons. The Cochrane Rob\u20102 and the CINeMA tools were used to assess risk of bias and the certainty of evidence, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>37 articles were included. Exercise was most effective for overall HRQoL (SMD\u2009=\u20091.00, 95% CI [0.43, 1.58]) and physical (SMD\u2009=\u20090.69, 95% CI [0.11, 1.27]), psychological (SMD\u2009=\u20090.93, 95% CI [0.37, 1.51]), and social (SMD\u2009=\u20090.57, 95% CI [0.06, 1.08]) domains. Mindfulness\u2010based interventions ranked second for overall HRQoL (SMD\u2009=\u20090.82, 95% CI [0.24, 1.40]). Cognitive behavioral therapy ranked second in the psychological domain (SMD\u2009=\u20090.73, 95% CI [0.16, 1.29]). Insufficient data precluded network meta\u2010analysis for environmental, independence, and spiritual domains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Linking Evidence to Action<\/jats:title>\n                    <jats:p>Future research should explore how different exercise types affect specific HRQoL dimensions and conduct large\u2010scale, head\u2010to\u2010head RCTs to confirm the efficacy of exercise, cognitive behavioral therapy, and mindfulness interventions, especially for the environmental, independence, and spiritual domains. Methodological improvements\u2014including blinding of outcome assessors, intention\u2010to\u2010treat analysis, standardized measurement tools, and protocol transparent reporting\u2014are needed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>PROSPERO: CRD420251118087<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/wvn.70167","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T04:57:40Z","timestamp":1785128260000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Non\u2010Pharmacological Interventions in Improving Health\u2010Related Quality of Life in People Living With\n                    <scp>HIV<\/scp>\n                    : A Bayesian Network Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0577-0503","authenticated-orcid":false,"given":"Mingyue","family":"Shi","sequence":"first","affiliation":[{"name":"School of Nursing Zhejiang Chinese Medical University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5419-5937","authenticated-orcid":false,"given":"Yunxian","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Nursing Zhejiang Chinese Medical University  Hangzhou Zhejiang 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