{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:01:51Z","timestamp":1777528911488,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T00:00:00Z","timestamp":1506038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Xenotransplantation"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The reconstruction of heart valves provides substantial benefits, particularly in the pediatric population. We present our experience using decellularized extracellular matrix (<jats:styled-content style=\"fixed-case\">dECM<\/jats:styled-content>, CorMatrix<jats:sup>\u00ae<\/jats:sup>) for aortic valve procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed the case histories of 6 patients (aged from 2\u00a0months \u2010 14\u00a0years) who underwent surgery for severe aortic valve stenosis (n\u00a0=\u00a04) or regurgitation (n\u00a0=\u00a02). Aortic valve repair was performed on all patients using <jats:styled-content style=\"fixed-case\">dECM<\/jats:styled-content> as a leaflet replacement or leaflet extension. Follow\u2010ups were performed using echocardiography. Reoperation was necessary in 4 cases, and the <jats:styled-content style=\"fixed-case\">dECM<\/jats:styled-content> was explanted and examined histologically and immunohistochemically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The early post\u2010operative period was uneventful, and the scaffold fulfilled the mechanical requirements. Significant valve insufficiency developed in 5 patients during the post\u2010operative period (119\u2010441\u00a0days postoperatively). In all specimens, only a migration of inflammatory cells was identified, which induced structural and functional changes caused by the chronic inflammatory response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest a mixed immunological response of remodeling and inflammation following the implantation. The expected process of seeding\/migration and remodeling of the bioscaffold into the typical 3\u2010layered architecture were not observed in our explanted specimens.<\/jats:p><\/jats:sec>","DOI":"10.1111\/xen.12341","type":"journal-article","created":{"date-parts":[[2017,9,23]],"date-time":"2017-09-23T04:38:41Z","timestamp":1506141521000},"source":"Crossref","is-referenced-by-count":26,"title":["Congenital aortic valve repair using CorMatrix<sup>\u00ae<\/sup>: A histologic evaluation"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7956-8579","authenticated-orcid":false,"given":"Michael","family":"Hofmann","sequence":"first","affiliation":[{"name":"Division of Congenital Cardiovascular Surgery University Children's Hospital Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin O.","family":"Schmiady","sequence":"additional","affiliation":[{"name":"Division of Congenital Cardiovascular Surgery University Children's Hospital Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara E.","family":"Burkhardt","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology University Children's Hospital Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitendu H.","family":"Dave","sequence":"additional","affiliation":[{"name":"Division of Congenital Cardiovascular Surgery University Children's Hospital Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"H\u00fcbler","sequence":"additional","affiliation":[{"name":"Division of Congenital Cardiovascular Surgery University Children's Hospital Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Kretschmar","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology University Children's Hospital Zurich  Zurich 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