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However, their significance in the context of <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content>\u2010compatible solid organ transplantation is only emerging. This review summarizes recent studies exploring these often neglected innate immune elements in situations related to sensitization and clinical graft rejection. A focus is placed on class\u2010switched IgG Nabs that develop amidst inflammation, rather than IgM Nabs abundant at the steady state, as new evidence point to their implication in serum reactivity to <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> and kidney graft failure. The involvement of innate B cells in the pathophysiology of <jats:styled-content style=\"fixed-case\">CAV<\/jats:styled-content> is also presented. Lastly, we discuss key questions that need answering to understand whether and how innate B\u2010cell immunity contributes to the outcome of solid organ transplantation.<\/jats:p>","DOI":"10.1111\/xen.12417","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T17:31:24Z","timestamp":1529343084000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["New insights on innate B\u2010cell immunity in transplantation"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9985-8389","authenticated-orcid":false,"given":"Emmanuel","family":"Zorn","sequence":"first","affiliation":[{"name":"Columbia Center for Translational Immunology New York Presbyterian Hospital Columbia University Medical Center  New York NY 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