{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:46:38Z","timestamp":1753879598949,"version":"3.41.2"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T00:00:00Z","timestamp":1536364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI13C0954"],"award-info":[{"award-number":["HI13C0954"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Xenotransplantation"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pig\u2010to\u2010nonhuman primate (<jats:styled-content style=\"fixed-case\">NHP<\/jats:styled-content>) islet transplantation has been widely conducted as a preclinical xenotransplantation model prior to human clinical trial. Portal vein thrombosis is one of the complications associated with islet infusion through the portal vein into the liver. Here, we briefly report severe case of ascites formation accompanied by portal vein thrombi after pig\u2010to\u2010<jats:styled-content style=\"fixed-case\">NHP<\/jats:styled-content> islet xenotransplantation in a rhesus monkey. Meticulous prophylactic treatment such as continuous heparin infusion should be implemented to prevent portal vein thrombi in pig\u2010to\u2010<jats:styled-content style=\"fixed-case\">NHP<\/jats:styled-content> islet transplantation models.<\/jats:p>","DOI":"10.1111\/xen.12460","type":"journal-article","created":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T20:37:43Z","timestamp":1536439063000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ascites formation accompanied by portal vein thrombosis after porcine islet xenotransplantation via the portal vein in Rhesus macaque (<i>Macaca mulatta<\/i>)"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0906-0117","authenticated-orcid":false,"given":"Jong\u2010Min","family":"Kim","sequence":"first","affiliation":[{"name":"Xenotransplantation Research Center Seoul National University Graduate School  Seoul Korea"},{"name":"Department of Microbiology and Immunology Seoul National University Graduate School  Seoul Korea"},{"name":"Institute of Endemic Diseases Seoul National University Graduate School  Seoul Korea"},{"name":"Cancer Research Institute Seoul National University Graduate School  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010Seop","family":"Shin","sequence":"additional","affiliation":[{"name":"Xenotransplantation Research Center Seoul National University Graduate School  Seoul Korea"},{"name":"Department of Microbiology and Immunology Seoul National University Graduate School  Seoul Korea"},{"name":"Institute of Endemic Diseases Seoul National University Graduate School  Seoul Korea"},{"name":"Cancer Research Institute Seoul National University Graduate School  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sungyoung","family":"Han","sequence":"additional","affiliation":[{"name":"Seoul Animal Medical Center Seoul National University Graduate School  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byoung\u2010Hoon","family":"Min","sequence":"additional","affiliation":[{"name":"Xenotransplantation Research Center Seoul National University Graduate School  Seoul Korea"},{"name":"Department of Microbiology and Immunology Seoul National University Graduate School  Seoul Korea"},{"name":"Institute of Endemic Diseases Seoul National University Graduate School  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won Young","family":"Jeong","sequence":"additional","affiliation":[{"name":"Xenotransplantation Research Center Seoul National University Graduate School  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ga Eul","family":"Lee","sequence":"additional","affiliation":[{"name":"Xenotransplantation Research Center Seoul National University Graduate School  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Xenotransplantation Research Center Seoul National University Graduate School  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seeun","family":"Kwon","sequence":"additional","affiliation":[{"name":"Xenotransplantation Research Center Seoul National University Graduate School  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunwoo","family":"Chung","sequence":"additional","affiliation":[{"name":"Xenotransplantation Research Center Seoul National University Graduate School  Seoul Korea"},{"name":"Department of Microbiology and Immunology Seoul National University Graduate School  Seoul Korea"},{"name":"Department of Biomedical Sciences Seoul National University Graduate School  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1249-6181","authenticated-orcid":false,"given":"Hee Jung","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Hallym University College of Medicine  Anyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4083-8791","authenticated-orcid":false,"given":"Chung\u2010Gyu","family":"Park","sequence":"additional","affiliation":[{"name":"Xenotransplantation Research Center Seoul National University Graduate School  Seoul Korea"},{"name":"Department of Microbiology and Immunology Seoul National University Graduate School  Seoul Korea"},{"name":"Institute of Endemic Diseases Seoul National University Graduate School  Seoul Korea"},{"name":"Cancer Research Institute Seoul National University Graduate School  Seoul Korea"},{"name":"Seoul Animal Medical Center Seoul National University Graduate School  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-1988"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2006.053447"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.178"},{"key":"e_1_2_5_5_1","unstructured":"CENTERCC.Collaborative Islet Transplantation Registry (CITR) 8th Annual Report.2012."},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03717.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13345"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.5500\/wjt.v6.i2.437"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000128332.71657.EA"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3089.2008.00482.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/TXD.0000000000000590"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368911X580563"},{"key":"e_1_2_5_13_1","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1097\/01.TP.0000098905.86445.0F","article-title":"Nicotinamide inhibits tissue factor expression in isolated human pancreatic islets: implications for clinical islet transplantation","volume":"76","author":"Moberg L","year":"2003","journal-title":"Transplantation"}],"container-title":["Xenotransplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fxen.12460","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/xen.12460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T18:58:07Z","timestamp":1694717887000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/xen.12460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,8]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/xen.12460"],"URL":"https:\/\/doi.org\/10.1111\/xen.12460","archive":["Portico"],"relation":{},"ISSN":["0908-665X","1399-3089"],"issn-type":[{"type":"print","value":"0908-665X"},{"type":"electronic","value":"1399-3089"}],"subject":[],"published":{"date-parts":[[2018,9,8]]},"assertion":[{"value":"2017-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12460"}}