{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T21:02:32Z","timestamp":1775509352074,"version":"3.50.1"},"reference-count":7,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T00:00:00Z","timestamp":1542326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Disease","doi-asserted-by":"crossref","award":["2T32AI007529-16A1"],"award-info":[{"award-number":["2T32AI007529-16A1"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Disease","doi-asserted-by":"crossref","award":["5T32AI007529-18"],"award-info":[{"award-number":["5T32AI007529-18"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Xenotransplantation"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>As outcomes in clinical liver transplantation steadily improve, demand continues to exceed supply, leading to a substantial disparity in organ availability. The translation of porcine liver xenotransplantation (LXT) into a clinical reality aims to address this dilemma. Our laboratory has previously established an applicable model of \u03b1\u20101,3\u2010galactosyltransferase knockout (GalT\u2010KO) pig\u2010to\u2010primate LXT with continuous human coagulation factor infusion and costimulation blockade. This report aims to further investigate the post\u2010LXT lipid and amino acid metabolism profile in our longest surviving recipients (25 and 29\u00a0days). Experimental samples and control samples, consisting of pre\u2010transplant porcine and baboon serum and plasma, were analyzed for standard lipid profiles and for amino acid levels. Lipid profiles of LXT recipients remained stable following xenotransplantation compared to donor porcine baseline levels. Amino acid concentrations also remained similar to baseline controls, with the exception of a 3\u2010fold <jats:italic>increase<\/jats:italic> in <jats:sc>l<\/jats:sc>\u2010ornithine and more than a 10\u2010fold <jats:italic>decrease<\/jats:italic> in <jats:sc>l<\/jats:sc>\u2010arginine post\u2010transplant when compared to both porcine and baboon baseline levels. The observed changes in <jats:sc>l<\/jats:sc>\u2010arginine are consistent with prior studies investigating the effects of graft preservation injury following liver transplantation. These results indicate that the porcine liver can maintain most biochemical profiles stably post\u2010operatively in baboons and suggest that arginine supplementation post\u2010LXT may potentially be useful for further prolongation of xenograft survival.<\/jats:p>","DOI":"10.1111\/xen.12473","type":"journal-article","created":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T09:42:48Z","timestamp":1542361368000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Amino acid and lipid profiles following pig\u2010to\u2010primate liver xenotransplantation"],"prefix":"10.1111","volume":"26","author":[{"given":"Jigesh A.","family":"Shah","sequence":"first","affiliation":[{"name":"Center for Transplantation Sciences Massachusetts General Hospital Harvard Medical School Boston Massachusetts"},{"name":"Division of Abdominal Transplant Surgery Duke University Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhukar S.","family":"Patel","sequence":"additional","affiliation":[{"name":"Center for Transplantation Sciences Massachusetts General Hospital Harvard Medical School Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Louras","sequence":"additional","affiliation":[{"name":"Center for Transplantation Sciences Massachusetts General Hospital Harvard Medical School Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9588-8580","authenticated-orcid":false,"given":"David H.","family":"Sachs","sequence":"additional","affiliation":[{"name":"Center for Transplantation Sciences Massachusetts General Hospital Harvard Medical School Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0461-5438","authenticated-orcid":false,"given":"Parsia A.","family":"Vagefi","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(68)91869-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3089.2012.00717.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001659"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14341"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12007"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.35058"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607101025003142"}],"container-title":["Xenotransplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fxen.12473","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/xen.12473","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/xen.12473","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/xen.12473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T12:47:23Z","timestamp":1694350043000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/xen.12473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,16]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1111\/xen.12473"],"URL":"https:\/\/doi.org\/10.1111\/xen.12473","archive":["Portico"],"relation":{},"ISSN":["0908-665X","1399-3089"],"issn-type":[{"value":"0908-665X","type":"print"},{"value":"1399-3089","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,16]]},"assertion":[{"value":"2018-07-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12473"}}