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Here, in a Mauritian cynomolgus macaque model of fully MHC\u2010matched allogeneic HSCT, we report reactivations of cynomolgus polyomavirus, lymphocryptovirus, and cytomegalovirus, macaque viruses analogous to HSCT\u2010associated human counterparts BK virus, Epstein\u2010Barr virus, and human cytomegalovirus. Viral replication in recipient macaques resulted in characteristic disease manifestations observed in HSCT patients, such as polyomavirus\u2010associated hemorrhagic cystitis and tubulointerstitial nephritis or lymphocryptovirus\u2010associated post\u2010transplant lymphoproliferative disorder. However, in most cases, the reconstituted immune system, alone or in combination with short\u2010term pharmacological intervention, exerted control over viral replication, suggesting engraftment of functional donor\u2010derived immunity. Indeed, the donor\u2010derived reconstituted immune systems of two long\u2010term engrafted HSCT recipient macaques responded to live attenuated yellow fever 17D vaccine (YFV 17D) indistinguishably from untransplanted controls, mounting 17D\u2010targeted neutralizing antibody responses and clearing YFV 17D within 14\u00a0days. Together, these data demonstrate that this macaque model of allogeneic HSCT recapitulates clinical situations of opportunistic viral infections in transplant patients and provides a pre\u2010clinical model to test novel prophylactic and therapeutic modalities.<\/jats:p>","DOI":"10.1111\/xen.12578","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T11:19:28Z","timestamp":1578914368000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Viral opportunistic infections in Mauritian cynomolgus macaques undergoing allogeneic stem cell transplantation mirror human transplant infectious disease complications"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7101-5160","authenticated-orcid":false,"given":"Helen L.","family":"Wu","sequence":"first","affiliation":[{"name":"Vaccine and Gene Therapy Institute Oregon Health &amp; Science University Beaverton Oregon"},{"name":"Oregon National Primate Research Center Oregon Health &amp; 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