{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T15:34:16Z","timestamp":1760369656210,"version":"3.41.2"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100016698","name":"Joint Fund of the National Natural Science Foundation of China and the Karst Science Research Center of Guizhou Province","doi-asserted-by":"publisher","award":["81870091","81941008","91642208"],"award-info":[{"award-number":["81870091","81941008","91642208"]}],"id":[{"id":"10.13039\/100016698","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Xenotransplantation"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Liver xenotransplantation (LXT) is greatly impeded by severe thrombocytopenia, anemia, and coagulopathy. Hepatic phagocytic cells are thought to play an important role in LXT\u2010induced thrombocytopenia and anemia. In this study, we investigated whether the lack of recipient CD47\u2010donor SIRP\u03b1 interaction, which is known to induce xenograft rejection by macrophages, exacerbates platelet and RBC depletion following LXT. We first addressed this question in the absence of anti\u2010donor immune responses using a syngeneic mouse liver transplantation (LT) model. Neither wild\u2010type (WT) nor CD47KO B6 mice developed thrombocytopenia following LT from WT B6 donors. Although a moderate decline in RBCs was detected following LT, there was no significant difference in RBC counts between WT and CD47KO recipients. Because mouse CD47 is cross\u2010reactive with rat SIRP\u03b1, we then compared thrombocytopenia and anemia between WT and CD47KO mice following rat LXT. Unlike syngeneic mouse LT, significant thrombocytopenia and anemia were detected following rat LXT. However, the severities of both platelet and RBC depletions were comparable between WT and CD47KO recipients. Furthermore, WT and CD47KO recipients showed a similar extent of early platelet activation. Our results indicate that CD47\u2010SIRP\u03b1 signaling does not significantly affect the loss of platelets or RBCs following LXT, suggesting that the limited cross\u2010reactivity between recipient CD47 and donor SIRP\u03b1 is not a significant risk factor for LXT\u2010induced thrombocytopenia and anemia.<\/jats:p>","DOI":"10.1111\/xen.12657","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T09:04:11Z","timestamp":1603875851000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Incompatibility between recipient CD47 and donor SIRP\u03b1 is not a key risk factor for thrombocytopenia or anemia following rat liver xenotransplantation in mice"],"prefix":"10.1111","volume":"28","author":[{"given":"Ting","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education The First Hospital of Jilin University  Changchun China"},{"name":"Department of Hepatobiliary and Pancreatic Surgery The First Hospital of Jilin University  Changchun China"},{"name":"National\u2010Local Joint Engineering Laboratory of Animal Models for Human Diseases  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanan","family":"Lv","sequence":"additional","affiliation":[{"name":"Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education The First Hospital of Jilin University  Changchun China"},{"name":"National\u2010Local Joint Engineering Laboratory of Animal Models for Human Diseases  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renren","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education The First Hospital of Jilin University  Changchun China"},{"name":"National\u2010Local Joint Engineering Laboratory of Animal Models for Human Diseases  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Guang","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education The First Hospital of Jilin University  Changchun China"},{"name":"National\u2010Local Joint Engineering Laboratory of Animal Models for Human Diseases  Changchun China"},{"name":"International Center of Future Science Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Hu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education The First Hospital of Jilin University  Changchun China"},{"name":"National\u2010Local Joint Engineering Laboratory of Animal Models for Human Diseases  Changchun 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