{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:15:33Z","timestamp":1790828133915,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:00:00Z","timestamp":1662595200000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TRR127"],"award-info":[{"award-number":["TRR127"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Xenotransplantation"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The potential for a donor\u2010derived transmission of porcine cytomegalovirus\/porcine roseolovirus (PCMV\/PRV) to the recipient has been recognized since pigs were considered candidate donors for xenotransplantation. This review gives a short description of the viral properties and summarizes the current evidence of the effects of PCMV\/PRV transmission in preclinical xenotransplantation. Despite evidence that PCMV\/PRV does not infect human and non\u2010human primate cells, activation in the transplanted organ and detrimental systemic complications have been described. As PCMV\/PRV is a herpesvirus able to establish latency, the importance of adequate screening of donor pigs is emphasized, as no efficient treatment is available. Furthermore, easy and successful ways of elimination of PCMV\/PRV from pig herds are indicated.<\/jats:p>","DOI":"10.1111\/xen.12775","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T06:24:03Z","timestamp":1662704643000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Porcine cytomegalovirus\/porcine roseolovirus (PCMV\/PRV): A threat for xenotransplantation?"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1059-3191","authenticated-orcid":false,"given":"Nicolas J.","family":"Mueller","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology, and University Zurich University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3244-6085","authenticated-orcid":false,"given":"Joachim","family":"Denner","sequence":"additional","affiliation":[{"name":"Institut of Virology Free University Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2014.05.014"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-018-1088-2"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2201422"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(76)90043-8"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/v11121108"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.10.4734-4740.2002"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005666"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01250206"},{"key":"e_1_2_12_10_1","first-page":"371","article-title":"Electron microscopy of porcine cytomegalovirus in pig lung macrophage cultures","volume":"26","author":"Val\u00ed\u010dek L.","year":"1979","journal-title":"Vet. 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