{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T13:31:24Z","timestamp":1781530284631,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Xenotransplantation"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Experience from human renal allotransplantation informs us that disturbances in serum calcium and phosphate levels are relatively common. Post\u2010transplant hypercalcemia is associated with an increased risk of recipient mortality, but not of graft loss or nephropathy, and post\u2010transplant hyperphosphatemia with an increased risk of both recipient mortality and death\u2010censored graft failure, but neither post\u2010transplant hypocalcemia nor hypophosphatemia is associated with adverse outcome.<\/jats:p><jats:p>Studies after pig\u2010to\u2010nonhuman primate kidney xenotransplantation have demonstrated consistent supranormal serum calcium and subnormal serum phosphate levels. If these trends in serum electrolyte levels were to occur following pig\u2010to\u2010human kidney xenotransplantation, the data from allotransplant studies would indicate an increased risk of recipient mortality (associated with hypercalcemia) but not of graft loss or nephropathy, and no adverse outcome from hypophosphatemia.<\/jats:p><jats:p>Furthermore, some nonhuman primates are now surviving in a healthy state for longer than a year after life\u2010supporting pig kidney transplantation, suggesting that chronic hypercalcemia and\/or hypophosphatemia are not detrimental to long\u2010term survival, and should not prevent clinical trials of pig kidney transplantation from being undertaken.<\/jats:p>","DOI":"10.1111\/xen.12785","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T11:47:30Z","timestamp":1666871250000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["What is the clinical relevance of deviant serum calcium and phosphate levels after pig\u2010to\u2010primate kidney xenotransplantation?"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1292-2147","authenticated-orcid":false,"given":"Aaron C. K.","family":"Lucander","sequence":"first","affiliation":[{"name":"Medical Scientist Training Program University of Alabama at Birmingham (UAB) Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Judd","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine University of Alabama at Birmingham (UAB) Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8899-9431","authenticated-orcid":false,"given":"David K. C.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Center for Transplantation Sciences Massachusetts General Hospital\/Harvard Medical School Charlestown Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,27]]},"reference":[{"issue":"2","key":"e_1_2_5_2_1","doi-asserted-by":"crossref","first-page":"e12723","DOI":"10.1111\/xen.12723","article-title":"Moving xenotransplantation to the clinic. 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