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In organ allotransplantation, current regimens infrequently include an mTOR\u2010I, which are positioned more commonly as alternative immunosuppressants. In clinical allotransplantation, long\u2010term efficacy has been established, but there is a significant incidence of adverse events, for example, inhibition of wound healing, buccal ulceration, anemia, hyperglycemia, dyslipidemia, and thrombocytopenia, some of which are dose\u2010dependent. mTOR\u2010Is have properties that may be especially beneficial in xenotransplantation. These include suppression of T cell proliferation, increases in the number of T regulatory cells, inhibition of pig graft growth, and anti\u2010inflammatory, anti\u2010viral, and anti\u2010cancer effects. We here review the potential benefits and risks of mTOR\u2010Is in xenotransplantation and suggest that the benefits exceed the adverse effects.<\/jats:p>","DOI":"10.1111\/xen.12802","type":"journal-article","created":{"date-parts":[[2023,4,8]],"date-time":"2023-04-08T05:45:51Z","timestamp":1680932751000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The case for the therapeutic use of mechanistic\/mammalian target of rapamycin (mTOR) inhibitors in xenotransplantation"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6216-4890","authenticated-orcid":false,"given":"Akihiro","family":"Maenaka","sequence":"first","affiliation":[{"name":"Center for Transplantation Sciences Department of Surgery Massachusetts General Hospital\/Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3267-906X","authenticated-orcid":false,"given":"Kohei","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Center for Transplantation Sciences Department of Surgery Massachusetts General Hospital\/Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4179-7365","authenticated-orcid":false,"given":"Hidetaka","family":"Hara","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Yunnan Agricultural University  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8899-9431","authenticated-orcid":false,"given":"David K. 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