{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:53:20Z","timestamp":1777661600936,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T00:00:00Z","timestamp":1690329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Xenotransplantation"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Xenotransplantation using pigs' liver offers a potentially alternative method to overcome worldwide donor shortage, or more importantly as a bridge to allotransplantation. However, it has been challenged by profound thrombocytopenia and fatal coagulopathy in non\u2010human primate models. Here we suggest that a left auxiliary technique can be a useful method to achieve extended survival of the xenograft. Fifteen consecutive liver xenotransplants were carried out in a pig\u2010to\u2010cynomolgus model. Right auxiliary technique was implemented in two cases, orthotopic in eight cases, and left auxiliary in five cases. None of the right auxiliary recipients survived after surgery due to hemorrhage during complex dissection between the primate's right lobe and inferior vena cava. Orthotopic recipients survived less than 7\u00a0days secondary to profound thrombocytopenia and coagulopathy. Two out of five left auxiliary xenotransplants survived more than 3\u00a0weeks without uncontrolled thrombocytopenia or anemia, with one of them surviving 34\u00a0days, the longest graft survival reported to date. Left auxiliary xenotransplant is a feasible approach in non\u2010human primate experiments, and the feared risk of thrombocytopenia and coagulopathy can be minimized. This may allow for longer evaluation of the xenograft and help better understand histopathological and immunological changes that occur following liver xenotransplantation.<\/jats:p>","DOI":"10.1111\/xen.12814","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T13:15:56Z","timestamp":1690377356000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Auxiliary liver xenotransplantation technique in a transgenic pig\u2010to\u2010non\u2010human primate model: A surgical approach to prolong survival"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2722-7817","authenticated-orcid":false,"given":"Kyo Won","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean S. W.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Suk","family":"Kim","sequence":"additional","affiliation":[{"name":"GenNBio Pyeongtaek\u2010Si Gyeonggi\u2010Do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimyung","family":"Choi","sequence":"additional","affiliation":[{"name":"Optipharm Inc. Cheongju\u2010si Chungcheongbuk\u2010do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joohyun","family":"Shim","sequence":"additional","affiliation":[{"name":"Optipharm Inc. Cheongju\u2010si Chungcheongbuk\u2010do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology Asan Medical Center Ulsan University Medical School Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Joo","family":"Kim","sequence":"additional","affiliation":[{"name":"GenNBio Pyeongtaek\u2010Si Gyeonggi\u2010Do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Berm","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(21)00328-9"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199603143341104"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2014.12.002"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.6002\/ect.2017.0045"},{"key":"e_1_2_9_6_1","first-page":"91","article-title":"Aborted donor hepatectomy in living donor liver transplantation: lessons learned","volume":"58","author":"Kutluturk K","year":"2020","journal-title":"S Afr J Surg"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.827535"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001319"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003722"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3089.2011.00679.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2012.01506.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001659"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14341"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12111"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000374067"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000525007.05496.95"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12164"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12657"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajp.20667"},{"key":"e_1_2_9_20_1","first-page":"177","article-title":"Morphologic and doppler findings from hepatic ultrasonography of normal cynomolgus monkeys (Macaca fascicularis)","volume":"56","author":"Lee KW","year":"2017","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02945.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001071"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/TXD.0000000000001038"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0000000000000578"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21622"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199705000-00005"}],"container-title":["Xenotransplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/xen.12814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T06:45:31Z","timestamp":1695365131000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/xen.12814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,26]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/xen.12814"],"URL":"https:\/\/doi.org\/10.1111\/xen.12814","archive":["Portico"],"relation":{},"ISSN":["0908-665X","1399-3089"],"issn-type":[{"value":"0908-665X","type":"print"},{"value":"1399-3089","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,26]]},"assertion":[{"value":"2023-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12814"}}