{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:33:28Z","timestamp":1788518008054,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T00:00:00Z","timestamp":1724630400000},"content-version":"vor","delay-in-days":56,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Xenotransplantation"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the clinically relevant anti\u2010CD40 antibody iscalimab for baseline immunosuppression in a preclinical pig\u2010to\u2010rhesus renal xenograft model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary Background Data<\/jats:title>\n                    <jats:p>CD40\/CD40L co\u2010stimulation blockade\u2010based immunosuppression has been more successful than calcineurin\u2010based protocols in prolonging xenograft survival in preclinical models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      GGTA1 knockout\/CD55 transgenic pig kidneys were transplanted into rhesus monkeys (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a06) receiving an iscalimab\u2010based immunosuppressive regimen.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Two grafts were lost early (22 and 26 days) because of ectatic donor ureters with otherwise normal histology. The other recipients survived 171, 315, 422, and 439 days with good renal function throughout the posttransplant course. None of the recipients experienced serious infectious morbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>It may be reasonable to evaluate an iscalimab\u2010based immunosuppressive regimen in clinical renal xenotransplantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/xen.12880","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T07:50:02Z","timestamp":1724658602000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Iscalimab Combined With Transient Tesidolumab Prolongs Survival in Pig\u2010to\u2010Rhesus Monkey Renal Xenografts"],"prefix":"10.1111","volume":"31","author":[{"given":"Andrew B.","family":"Adams","sequence":"first","affiliation":[{"name":"Department of Surgery University of Minnesota School of Medicine  Minneapolis Minnesota 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