{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:03:38Z","timestamp":1791810218636,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Xenotransplantation"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This survey explored the ethical, legal, and social implications (ELSI) of xenotransplantation in adolescents and young adults. A web\u2010based questionnaire targeting individuals aged 12\u201330 was conducted via a Japanese government platform. Results from 113 responses revealed generally positive attitudes toward xenotransplantation, particularly among males, and also highlighted concerns about infection, identity, and animal ethics. Most respondents conditionally accepted xenotransplantation, emphasizing informed consent and societal awareness. Xenotransplantation was ranked lowest in treatment priority compared to regenerative medicine and human organ transplantation. The survey captured respondents\u2019 feelings about themselves or friends receiving xenotransplants and highlighted issues to address before clinical use in Japan. Findings were presented at a national expert committee meeting, emphasizing the importance of including adolescent and young adults\u2019 perspectives in research and review processes. As Japan considers xenotransplantation research under regulation, this survey offers global insights to support ELSI\u2010aligned development.<\/jats:p>","DOI":"10.1111\/xen.70091","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T08:56:01Z","timestamp":1763628961000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Governmental Questionnaire Survey on Adolescent and Young Adults\u2019 Views on the Clinical Application of Xenotransplantation"],"prefix":"10.1111","volume":"32","author":[{"given":"Satoshi","family":"Hosoya","sequence":"first","affiliation":[{"name":"Research and Development Policy Division Health Policy Bureau Ministry of Health Labour and Welfare  Chiyoda Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Ukon","sequence":"additional","affiliation":[{"name":"Research and Development Policy Division Health Policy Bureau Ministry of Health Labour and Welfare  Chiyoda Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Morita","sequence":"additional","affiliation":[{"name":"Research and Development Policy Division Health Policy Bureau Ministry of Health Labour and Welfare  Chiyoda Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Yasuoka","sequence":"additional","affiliation":[{"name":"Policy Planning Division Administrator's Secretariat Children and Families Agency  Chiyoda Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Kamisato","sequence":"additional","affiliation":[{"name":"Department of Medical Legal Research National Center for Child Health and Development  Setagaya Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Sugihara","sequence":"additional","affiliation":[{"name":"Research and Development Policy Division Health Policy Bureau Ministry of Health Labour and Welfare  Chiyoda Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Research and Development Policy Division Health Policy Bureau Ministry of Health Labour and Welfare  Chiyoda Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2201422"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02471-9"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2120238"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2412747"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-08799-1"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinsp.2023.100170"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12848"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2024.07.018"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0002082020"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3089.2006.00334.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1088\/0963-6625\/11\/4\/303"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000004968"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-025-07783-9"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2023.4681"},{"key":"e_1_2_11_16_1","unstructured":"The Cabinet Office \u201cSurvey on Public and Researcher Attitudes Regarding Animal Use in Regenerative Medicine Research 70th Expert Panel on Bioethics \u201d [in Japanese] (The Cabinet Office 2012) https:\/\/www8.cao.go.jp\/cstp\/tyousakai\/life\/haihu70\/siryo5.pdf."},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/16094069251333886"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2024.100900"},{"key":"e_1_2_11_19_1","article-title":"Exclusive: Longest Human Transplant of Pig Kidney Fails","author":"Cohen J.","year":"2025","journal-title":"Science"},{"key":"e_1_2_11_20_1","article-title":"The Impact of Revised Regenerative Medicine Regulations on Unapproved Gene Therapies in Japan","volume":"25","author":"Ukon Y.","year":"2025","journal-title":"Molecular Therapy"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2015.03.012"},{"key":"e_1_2_11_22_1","unstructured":"The Ministry of Health Labour and Welfare \u201cImplementation of Xenotransplantation Under the Act on the Safety of Regenerative Medicine \u201d [in Japanese] (The Ministry of Health Labour and Welfare 2024) https:\/\/www.mhlw.go.jp\/content\/10808000\/001318142.pdf."},{"key":"e_1_2_11_23_1","unstructured":"The Ministry of Health Labour and Welfare \u201cThe Results of the Questionnaire Survey on Xenotransplantation \u201d [in Japanese] (The Ministry of Health Labour and Welfare 2025) https:\/\/www.mhlw.go.jp\/content\/10808000\/001389851.pdf."},{"key":"e_1_2_11_24_1","unstructured":"The Ministry of Health Labour and Welfare \u201cGuidelines on Risk Control of Xenograft\u2010Derived Infections Associated with the Practice of Xenotransplantation \u201d [in Japanese] (The Ministry of Health Labour and Welfare 2025) https:\/\/www.mhlw.go.jp\/content\/001377933.pdf."}],"container-title":["Xenotransplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/xen.70091","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/xen.70091","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/xen.70091","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:01:02Z","timestamp":1785452462000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/xen.70091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/xen.70091"],"URL":"https:\/\/doi.org\/10.1111\/xen.70091","archive":["Portico"],"relation":{},"ISSN":["0908-665X","1399-3089"],"issn-type":[{"value":"0908-665X","type":"print"},{"value":"1399-3089","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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