{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:57:51Z","timestamp":1785455871326,"version":"3.56.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Xenotransplantation"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The shortage of human organs for transplantation is a pressing global issue, propelling interest in xenotransplantation as a viable alternative. This study aims to assess the knowledge, attitudes, and practices (KAP) of healthcare workers in Saudi Arabia regarding xenotransplantation, particularly in light of recent advancements in the field.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cross\u2010sectional electronic survey was conducted from June 5 to June 19, 2024, targeting Healthcare workers across various specialties in Saudi Arabia. A minimum sample size of 386 participants was determined, and data were collected using a validated survey administered via SurveyMonkey. Descriptive statistics, Chi\u2013square tests,\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests, and logistic regression analyses were performed to evaluate associations and identify predictors of KAP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 2689 healthcare workers participated in the survey. The majority were female (58.6%) and under 25 years old (62.6%). The overall knowledge score was moderate (mean\u00a0=\u00a04.69\/9), while attitudes toward xenotransplantation reflected low to moderate acceptance (mean\u00a0=\u00a02.1\/5). Awareness of Islamic approval for human organ transplantation was noted in 57.3% of participants, with only 45.4% expecting future approval for xenotransplantation. Perceived barriers included psychological risks, social stigma, and ethical concerns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study highlights the need for enhanced education and engagement among Healthcare workers regarding xenotransplantation in Saudi Arabia. Understanding local attitudes is crucial for the successful implementation of xenotransplantation technologies, considering the unique cultural and ethical landscape of the region. Further research is warranted to explore the implications of these findings for policy and practice in xenotransplantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/xen.70102","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T10:55:13Z","timestamp":1764932113000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessing Knowledge, Attitudes, and Practices of Healthcare Workers in Saudi Arabia Towards Xenotransplantation: Insights From a Cross\u2010Sectional Survey"],"prefix":"10.1111","volume":"32","author":[{"given":"Khalid","family":"Alhasan","sequence":"first","affiliation":[{"name":"Pediatric Department College of Medicine King Saud University Riyadh Saudi Arabia"},{"name":"Kidney and Pancreas Health Center Organ Transplant Center of Excellence King Faisal Specialist Hospital and Research Center Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi","family":"Aljamaan","sequence":"additional","affiliation":[{"name":"Critical Care Department College of Medicine King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawaf","family":"Alshuraym","sequence":"additional","affiliation":[{"name":"King Saud University Medical City King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehab B.","family":"Albakr","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Nephrology College of Medicine King Saud University Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amull","family":"Fariss","sequence":"additional","affiliation":[{"name":"King Saud University Medical City King Saud University Riyadh Saudi 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Transplant Center of Excellence King Faisal Specialist Hospital and Research Center Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah F.","family":"Albukhari","sequence":"additional","affiliation":[{"name":"College of Medicine King Abdulaziz University Rabigh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa A.","family":"Hakami","sequence":"additional","affiliation":[{"name":"King Fahd Central Hospital Jazan Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Sinha","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology Institute of Child Health Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira","family":"Abassi","sequence":"additional","affiliation":[{"name":"Abdominal Transplant and Hepatobiliary Surgery Center Organ Transplant Center of Excellence King Faisal Specialist Hospital and Research Center Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansour","family":"Tawfeeq","sequence":"additional","affiliation":[{"name":"Department of Transplant Surgery Multiorgan Transplant Center King Fahad Specialist Hospital Dammam Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jameela A.","family":"Kari","sequence":"additional","affiliation":[{"name":"Pediatric Nephrology Unit Faculty of Medicine and Pediatric Nephrology Center of Excellence King Abdulaziz University Hospital King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rezqah F.","family":"AlDhaferi","sequence":"additional","affiliation":[{"name":"Kidney and Pancreas Health Center Organ Transplant Center of Excellence King Faisal Specialist Hospital and Research Center Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupesh","family":"Raina","sequence":"additional","affiliation":[{"name":"Department of Nephrology Clevelnd Clinic Akron General and Akron Children Hospital Akron Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq","family":"Ali","sequence":"additional","affiliation":[{"name":"Kidney and Pancreas Health Center Organ Transplant Center of Excellence King Faisal Specialist Hospital and Research Center Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter C.","family":"Broering","sequence":"additional","affiliation":[{"name":"Kidney and Pancreas Health Center Organ Transplant Center of Excellence King Faisal Specialist Hospital and Research Center Riyadh Saudi Arabia"},{"name":"Abdominal Transplant and Hepatobiliary Surgery Center Organ Transplant Center of Excellence King Faisal Specialist Hospital and Research Center Riyadh Saudi 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