{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:03:32Z","timestamp":1791810212837,"version":"4.3.4"},"reference-count":103,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Xenotransplantation"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Xenotransplantation has entered a phase of accelerated clinical translation, necessitating renewed international consensus on governance, ethics, safety, and regulatory oversight. In September 2025, the International Xenotransplantation Association (IXA), in partnership with The Transplantation Society (TTS) and with engagement from the World Health Organization (WHO), convened a Global Consultation in Geneva to review, update, and harmonise international guidance for clinical xenotransplantation. This IXA consultation marked the twentieth anniversary of the first WHO Xenotransplantation Advisory Consultation in 2005 and built upon the foundational principles established through the Changsha Communiqu\u00e9 (2008, 2011 and 2018) and subsequent IXA and WHO\u2010led initiatives. Responding to rapid scientific advances, including some defined donor genetic standards, improved immunosuppression, enhanced biosecurity, and strengthened infectious disease surveillance, the IXA undertook an 18\u2011month, structured, evidence\u2011based revision process. Seven expert working groups, comprising approximately forty internationally recognised specialists from fourteen countries, reviewed developments across source animal standards and biosecurity, clinical trial design and oversight, immunosuppression and patient management, infectious disease risk and surveillance, ethical and legal frameworks, international governance, and emerging technologies. Draft recommendations were further refined through iterative consultation and plenary deliberation at the in\u2011person meeting held in Geneva, September 2025. The consultation proposed updated Principles and Recommendations directed to WHO, national regulators, investigators and sponsors, and the IXA\/TTS communities. Key elements include proportionate risk benefit assessments, robust donor and recipient surveillance, long\u2011term biobanking and monitoring, transparency and public engagement, harmonised regulatory oversight consistent with existing allotransplantation frameworks, and equitable access to future clinical applications. The revised guidance aligns with contemporary regulatory expectations of major international jurisdictions regulatory authorities including (AEMPS, ANMAT, CONABIA, CONFEPRIS, EMA, FDA, GTAC, HC, IEC, INCUCAI, Medsafe, MFDS, MHRA, MHLW, NMPA, NZGTAC, MFDS, MHRA, TGA); and consolidates international consensus at a critical juncture for the field. This IXA Global Consultation provides an authoritative, forward\u2011looking framework to support safe, ethical, and globally coordinated clinical xenotransplantation as it transitions from experimental innovation to regulated clinical practice.<\/jats:p>","DOI":"10.1111\/xen.70157","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T05:08:25Z","timestamp":1785820105000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Global Consultation for Clinical Xenotransplantation: International Xenotransplantation Association Consensus and Communiqu\u00e9 Update"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8638-3468","authenticated-orcid":false,"given":"Wayne J.","family":"Hawthorne","sequence":"first","affiliation":[{"name":"Department of Surgery Westmead Hospital Westmead Institute for Medical Research Faculty of Medicine and Health University of Sydney  Westmead NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0430-9510","authenticated-orcid":false,"given":"Eckhard","family":"Wolf","sequence":"additional","affiliation":[{"name":"Gene Center Ludwig Maximilian University of Munich (LMU)  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Cowan","sequence":"additional","affiliation":[{"name":"Immunology Research Centre St Vincent's Hospital University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Engineering Center for Xenotransplantation The Third Xiangya Hospital Central\u2010South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4013-6714","authenticated-orcid":false,"given":"Ik Jin","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Surgery Konkuk University Hospital Konkuk University  Seoul South\u2010Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Brenner","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Klinikum Gro\u00dfhadern Ludwig Maximilian University of Munich (LMU)  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9690-4351","authenticated-orcid":false,"given":"Greg","family":"Korbutt","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Alberta  Edmonton AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9050-0436","authenticated-orcid":false,"given":"Raphael P. H.","family":"Meier","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Sykes","sequence":"additional","affiliation":[{"name":"Columbia Center for Translational Immunology Columbia University College of Physicians and Surgeons Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9o H.","family":"B\u00fchler","sequence":"additional","affiliation":[{"name":"Cantonal Hospital Fribourg Faculty of Science and Medicine University of Fribourg  Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0727-7163","authenticated-orcid":false,"given":"Linda","family":"Scobie","sequence":"additional","affiliation":[{"name":"Department of Biological and Biomedical Sciences School of Health and Life Sciences Glasgow Caledonian University  Glasgow Scotland UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Garkavenko","sequence":"additional","affiliation":[{"name":"NZeno Limited  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunil","family":"Kim","sequence":"additional","affiliation":[{"name":"Optipharm, Inc.  Cheongju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0592-2592","authenticated-orcid":false,"given":"Daniel J.","family":"Hurst","sequence":"additional","affiliation":[{"name":"Department of Medical Education &amp; Scholarship Rowan\u2010Virtua School of Osteopathic Medicine  Stratford New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3764-4590","authenticated-orcid":false,"given":"Richard N. Pierson","family":"III","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery and Center for Transplantation Sciences Department of Surgery Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4179-8891","authenticated-orcid":false,"given":"Robert","family":"Rieben","sequence":"additional","affiliation":[{"name":"Department For BioMedical Research (DBMR) University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Pascual","sequence":"additional","affiliation":[{"name":"Transplantation Center Department of Surgery Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Scholes\u2010Robertson","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health Faculty of Medicine and Health University of Sydney  Westmead NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7855-5055","authenticated-orcid":false,"given":"Emanuele","family":"Cozzi","sequence":"additional","affiliation":[{"name":"Transplant Immunology Unit Padua University Hospital  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri\u00e1n","family":"Abalovich","sequence":"additional","affiliation":[{"name":"Eva Per\u00f3n Hospital of San Martin  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Loupy","sequence":"additional","affiliation":[{"name":"Department of Kidney Transplantation Assistance Publique \u2010 H\u00f4pitaux de Paris Universit\u00e9 Paris Cit\u00e9 Paris Institute for Transplantation and Organ Regeneration  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetaka","family":"Hara","sequence":"additional","affiliation":[{"name":"The Transplantation Institute of the Second Affiliated Hospital Hainan Medical University  Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1540-2996","authenticated-orcid":false,"given":"Rita","family":"Bottino","sequence":"additional","affiliation":[{"name":"Imagine Islet Center Imagine Pharma  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burcin","family":"Ekser","sequence":"additional","affiliation":[{"name":"Division of Intraabdominal Transplant Department of Surgery Stritch School of Medicine Loyola University Medical Center Loyola University Chicago  Maywood Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4654-783X","authenticated-orcid":false,"given":"Muhammad M.","family":"Mohiuddin","sequence":"additional","affiliation":[{"name":"Department of Surgery Cardiac Xenotransplantation Program University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2671-3311","authenticated-orcid":false,"given":"Jay","family":"Fishman","sequence":"additional","affiliation":[{"name":"Harvard Medical School Transplant Infectious Disease and Compromised Host Program and Transplant Center Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1355609"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12821"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.20506\/rst.24.1.1546"},{"key":"e_1_2_15_5_1","unstructured":"IXA.IXA Mission statement https:\/\/tts.org\/ixa\u2010about\/ixa\u2010history\u2010mission. Accesed 20thDec 2025."},{"key":"e_1_2_15_6_1","unstructured":"WHO\/CDS\/CSR\/EPH.WHO Guidance on xenogeneic infection\/disease surveillance and response: a strategy for international cooperation and coordination.2001."},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3089.2003.00067.x"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200309253491320"},{"key":"e_1_2_15_9_1","doi-asserted-by":"crossref","unstructured":"WHO. Fifty\u2010seventh World Health Assembly Agenda Item 12.14 May 22 2004. Resolution 57.18.2004.","DOI":"10.7748\/ns.18.22.12.s29"},{"key":"e_1_2_15_10_1","volume-title":"World Health Organization. Statement From the Xenotransplantation Advisory Consultation","author":"WHO","year":"2005"},{"key":"e_1_2_15_11_1","volume-title":"First WHO Global Consultation on Regulatory Requirements for Xenotransplantation Clinical Trials","author":"WHO","year":"2008"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3089.2009.00520.x"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3089.2012.00693.x"},{"key":"e_1_2_15_14_1","first-page":"2011","volume-title":"Second WHO Global Consultation on Regulatory Requirements for Xenotransplantation Clinical Trials","author":"WHO","year":"2011"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12513"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2020.05.034"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/ti.2024.13681"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-animal-021122-102606"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvac180"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12219"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02210.x"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12664"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2018.03.006"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.100978"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan4187"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfae023"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12744"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2201422"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-025-02851-w"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2412747"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15916"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03429-1"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-08799-1"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-024-00853-8"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2025.06.022"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2023.05.010"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2024.03.012"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.70002"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.70003"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.70053"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2025.10.005"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12516"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2025.12.012"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.898948"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.70017"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-022-00624-6"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2120238"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12836"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-09847-6"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2207462"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra064928"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(99)00315-2"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14725"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2025.06.016"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14091926"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3089.2009.00547.x"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12231"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2022.12.013"},{"key":"e_1_2_15_59_1","volume-title":"U.S.D., Source Animal, Product, Preclinical, and Clinical Issues Concerning the Use of Xenotransplantation Products in Humans","author":"Food and Drug Administration C","year":"2016"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13909"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12156"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-73150-9"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000232"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00775-4"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.3390\/v11070650"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.230.2.244"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-3-91"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0397-282"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.12.9986-9991.1998"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1138025100"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12102"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12815"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12594"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.10575"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3089.2004.00196.x"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000005286"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.70016"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12604"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.70091"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11673-024-10377-5"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000004968"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12847"},{"key":"e_1_2_15_83_1","volume-title":"Ethical Considerations for First\u2010In\u2010Human Pig Kidney Xenotransplant Clinical Trials","author":"Maschke K. J.","year":"2025"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000005367"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.70001"},{"key":"e_1_2_15_86_1","unstructured":"Confederation S. Transplantation Act (SR 810.21)2004."},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/hcs2.91"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)00712-3"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0003542022"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.1177\/09636625241232098"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.1177\/15269248241237817"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000004016"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.3389\/ti.2024.13349"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12602"},{"key":"e_1_2_15_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12603"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajt.2024.03.015"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.3389\/ti.2024.13594"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-03801-9"},{"key":"e_1_2_15_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)00195-3"},{"key":"e_1_2_15_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.70058"},{"key":"e_1_2_15_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01349-1"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03087-3"},{"key":"e_1_2_15_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-02972-1"},{"key":"e_1_2_15_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-09846-7"}],"container-title":["Xenotransplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/xen.70157","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/xen.70157","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/xen.70157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:46:17Z","timestamp":1787564777000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/xen.70157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":103,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/xen.70157"],"URL":"https:\/\/doi.org\/10.1111\/xen.70157","archive":["Portico"],"relation":{},"ISSN":["0908-665X","1399-3089"],"issn-type":[{"value":"0908-665X","type":"print"},{"value":"1399-3089","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-06-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70157"}}