{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:53:45Z","timestamp":1792180425612,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Xenotransplantation"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The objective of this review is to map and synthesize the existing literature regarding informed consent for porcine islet xenotransplantation for the treatment of Type 1 Diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The search was conducted in May 2025 through the following databases: PubMed, SCOPUS, EMBASE, and CINAHL. Broad search strings were used to combine the text words \u201cislet\u201d AND \u201cxenotransplantation\u201d AND \u201cconsent\u201d or similar permutations and combinations. Peer\u2010reviewed articles were included if they were published between January 1990 and May 2025 and written in English. The final search results were manually exported to a reference manager system (Zotero), and the PRISMA\u2010ScR flow diagram was created to depict the data extraction process.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 134 sources, 7 articles met eligibility for this scoping review. Although clinical studies have been sporadically conducted, there is a lack of literature describing informed consent for islet xenotransplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This review highlighted a scarcity of scholarly discourse and published guidance on informed consent specifically in the context of islet xenotransplantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/xen.70158","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T14:51:38Z","timestamp":1784991098000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Review of Informed Consent for Porcine Islet Xenotransplantation to Treat Type 1 Diabetes"],"prefix":"10.1111","volume":"33","author":[{"given":"Jennifer","family":"Kovalcik","sequence":"first","affiliation":[{"name":"Rowan\u2010Virtua School of Osteopathic Medicine  Stratford New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheetal","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Rowan\u2010Virtua School of Osteopathic Medicine  Stratford New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mairead","family":"Higgins","sequence":"additional","affiliation":[{"name":"Rowan\u2010Virtua School of Osteopathic Medicine  Stratford New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0592-2592","authenticated-orcid":false,"given":"Daniel J.","family":"Hurst","sequence":"additional","affiliation":[{"name":"Department of Medical Education &amp; Scholarship Rowan\u2010Virtua School of Osteopathic Medicine  Stratford New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/tp.0000000000004144"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-29071-8_6"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12790"},{"key":"e_1_2_10_5_1","unstructured":"U.S. Department of Health and Human Services Secretary's Advisory Committee on Xenotransplantation.Informed Consent in Clinical Research Involving Xenotransplantation. Accessed July 29 2025 https:\/\/www.tts.org\/images\/stories\/pdfs\/SACX\u2010informed\u2010consent.pdf."},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12910\u2010021\u201000607\u20105"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12196"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1355609"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0000000000000678"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/ti.2023.11705"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12328"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618\u2010025\u201002626\u20100"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20106143.2006.01336.x"},{"key":"e_1_2_10_14_1","unstructured":"World Health Organization.First WHO Global Consultation on Regulatory Requirements for Xenotransplantation Clinical Trials.Changsha: The Changsha Communiqu\u00e9. Accessed August 7 2025 https:\/\/www.tts.org\/images\/stories\/ixa\/regulatory_documents\/5_WHO_Global_Consultation_Communique_Changsha_China_\u2010_November_2008.pdf."},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.14876"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000004968"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12847"}],"container-title":["Xenotransplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/xen.70158","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/xen.70158","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/xen.70158","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:17:13Z","timestamp":1792178233000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/xen.70158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/xen.70158"],"URL":"https:\/\/doi.org\/10.1111\/xen.70158","archive":["Portico"],"relation":{},"ISSN":["0908-665X","1399-3089"],"issn-type":[{"value":"0908-665X","type":"print"},{"value":"1399-3089","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2025-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70158"}}