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Based on the information currently available, here, we propose a new and more comprehensive model to better understand the dynamics of the infection. This mathematical deterministic model was formulated considering: (i) the three clinical forms in humans: acute, chronic indeterminate and chronic with determinate pathology, (ii) the three main modes of transmission in the human population: vector\u2010borne, congenital and transfusional, (iii) populations of triatomines and dogs as the main domestic reservoirs of <jats:italic>T<\/jats:italic>.\u00a0<jats:italic>cruzi<\/jats:italic> and (iv) open populations. A numerical simulation was also performed to estimate the initial spread of the infection in a typical rural household in the endemic zone of the <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>rgentine <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>ran <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>haco. We also analysed the incidence of infected individuals corresponding to each of the three species (humans\/triatomines\/dogs) over times until the appearance of the first case in the other species. The model predicts that, in the absence of control measures, a few infected individuals are sufficient for the establishment and dispersion of the infection in all the inhabitants of the household. The model proposed and the results obtained allow describing the consequences of the presence of infected individuals in any of the three species considered in the dynamics and the output of the infection.<\/jats:p>","DOI":"10.1111\/zph.12104","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T11:18:46Z","timestamp":1392635926000},"page":"545-559","source":"Crossref","is-referenced-by-count":9,"title":["Modelling <scp>A<\/scp>merican <scp>T<\/scp>rypanosomiasis in an Endemic Zone: Application to the Initial Spread of Household Infection in the <scp>A<\/scp>rgentine <scp>C<\/scp>haco"],"prefix":"10.1111","volume":"61","author":[{"given":"M. C.","family":"Fabrizio","sequence":"first","affiliation":[{"name":"Departamento de M\u00e9todos Cuantitativos y Sistemas de Informaci\u00f3n Facultad de Agronom\u00eda Universidad de Buenos Aires  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. J.","family":"Schweigmann","sequence":"additional","affiliation":[{"name":"Departamento de Ecolog\u00eda, Gen\u00e9tica y Evoluci\u00f3n Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. J.","family":"Bartoloni","sequence":"additional","affiliation":[{"name":"Departamento de M\u00e9todos Cuantitativos y Sistemas de Informaci\u00f3n Facultad de Agronom\u00eda Universidad de Buenos Aires  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762011000200019"},{"key":"e_1_2_6_3_1","unstructured":"Barbieri G. E.Ramirez R.Manzur L.Moran L.Loza M.Iglesias M.Alcorta andP.Yachelini 2007:Incidencia de transmisi\u00f3n de enfermedad de Chagas cong\u00e9nito (eChc) en Santiago del Estero. 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