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The aims of this study were to identify factors associated with this disease described in different observational studies and to combine the coinciding factors in at least four studies using meta\u2010analyses, to obtain a pooled odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) as measure of infection risk. A literature search was performed in electronic databases, electronic databases of specific journals and search engines to find studies published in English, Spanish and Portuguese available from January 1960 to January 2015. Two hundred and eighteen factors were identified in 31 publications including cross\u2010sectional and case\u2013control studies. Finally, independent meta\u2010analyses were performed with six different variables, which included between 4 and 8 articles. The pooled <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> indicated that the variables \u2018mixed\u2010breed dogs\u2019, \u2018flooding occurrence in the habitat of the dog\u2019 and \u2018working dogs\u2019 were risk factors for leptospirosis, while \u2018being a dog less than 1\u00a0year old\u2019 was a protective factor; however, all these associations were not statistically significant. Otherwise, the variables \u2018male dog\u2019 and \u2018urban dog\u2019 were statistically significant risk factors for infection. This study highlights the need for more formal studies on the epidemiology of canine leptospirosis. Nevertheless, the study revealed that some risk factors for infection coincided in different observational studies. These factors could be considered to raise suspicion about the disease, especially when there is a history of exposure to the bacteria.<\/jats:p>","DOI":"10.1111\/zph.12236","type":"journal-article","created":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T09:09:05Z","timestamp":1446196145000},"page":"328-336","source":"Crossref","is-referenced-by-count":38,"title":["Meta\u2010Analyses of Factors Associated with Leptospirosis in Domestic Dogs"],"prefix":"10.1111","volume":"63","author":[{"given":"L.","family":"Az\u00f3car\u2010Aedo","sequence":"first","affiliation":[{"name":"Graduate School Faculty of Veterinary Sciences Universidad Austral de Chile Valdivia Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Monti","sequence":"additional","affiliation":[{"name":"Preventive Veterinary Medicine Department Faculty of Veterinary Sciences Universidad Austral de Chile Valdivia Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0450.2006.00922.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-09352007000100012"},{"key":"e_1_2_8_4_1","first-page":"167","article-title":"Increase in seroprevalence of canine leptospirosis and its risk factors, Ontario 1998\u20102006","volume":"73","author":"Alton G.","year":"2009","journal-title":"Can. 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