{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:03:27Z","timestamp":1783040607519,"version":"3.54.6"},"reference-count":58,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,1,18]],"date-time":"2016-01-18T00:00:00Z","timestamp":1453075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zoonoses and Public Health"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Hepatitis E has become an emerging infection in many European countries. We analysed the prevalence of hepatitis E virus (<jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>) infection in selected population groups in Croatia. Overall <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> IgG seropositivity was 5.6%, while 1.9% participants showed IgM antibodies suggestive of recent infection. No IgM\u2010positive sample was positive for <jats:styled-content style=\"fixed-case\">HEV RNA<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> IgG antibodies were most prevalent in alcohol abusers (8.9%) and war veterans (8.6%), compared with 6.1% among injecting drug users and 2.7% in healthcare professionals. No individual with high\u2010risk sexual behaviour tested <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> seropositive. <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> IgG positivity increased significantly with age from 1.8% to 2.3% in individuals younger than 40\u00a0years to 11.3% in individuals older than 50\u00a0years (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.023). The mean age of <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\u2010positive participants was significantly higher than that of <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\u2010negative participants (50.9\u00a0\u00b1\u00a011.8\u00a0years versus 41.2\u00a0\u00b1\u00a011.8\u00a0years, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.008). Seroprevalence rates were significantly higher in residents of suburban and rural areas compared with residents of urban areas (14.5% versus 2.5%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003). Additionally, an increasing prevalence of <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> IgG antibodies was observed from 1.8% in participants living in families with two household members to 12.1% in those living with more than four members (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.046). Gender, marital status, educational level, sexual orientation, source of drinking water, history of blood transfusions, surgical procedures, tattooing and travelling were not associated with <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> seroprevalence. Logistic regression showed that living in suburban\/rural areas was the main risk factor for <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> seropositivity (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a06.67; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.89\u201325.0; <jats:styled-content style=\"fixed-case\">AOR<\/jats:styled-content>\u00a0=\u00a07.14, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.89\u201325.0).<\/jats:p>","DOI":"10.1111\/zph.12254","type":"journal-article","created":{"date-parts":[[2016,1,18]],"date-time":"2016-01-18T14:22:41Z","timestamp":1453126961000},"page":"494-502","source":"Crossref","is-referenced-by-count":20,"title":["Seroepidemiology of Hepatitis E in Selected Population Groups in Croatia: A Prospective Pilot Study"],"prefix":"10.1111","volume":"63","author":[{"given":"T.","family":"Vilibic\u2010Cavlek","sequence":"first","affiliation":[{"name":"Department of Virology Croatian National Institute of Public Health Zagreb Croatia"},{"name":"School of Medicine University of Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Vilibic","sequence":"additional","affiliation":[{"name":"Vrapce University Psychiatric Hospital Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Kolaric","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Teaching Institute \u2018Dr Andrija Stampar\u2019 Zagreb Croatia"},{"name":"School of Medicine University of Rijeka Rijeka Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Jemersic","sequence":"additional","affiliation":[{"name":"Department of Virology Croatian Veterinary Institute Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Kucinar","sequence":"additional","affiliation":[{"name":"Department of Microbiology Istria County Institute of Public Health Pula Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Barbic","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infectious Diseases with Clinic Faculty of Veterinary Medicine University of Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bagaric","sequence":"additional","affiliation":[{"name":"Vrapce University Psychiatric Hospital Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Stevanovic","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infectious Diseases with Clinic Faculty of Veterinary Medicine University of Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Tabain","sequence":"additional","affiliation":[{"name":"Department of Virology Croatian National Institute of Public Health Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sviben","sequence":"additional","affiliation":[{"name":"School of Medicine University of Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Jukic","sequence":"additional","affiliation":[{"name":"School of Medicine University of Zagreb Zagreb Croatia"},{"name":"Vrapce University Psychiatric Hospital Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Mlinaric\u2010Galinovic","sequence":"additional","affiliation":[{"name":"Department of Virology Croatian National Institute of Public Health Zagreb Croatia"},{"name":"School of Medicine University of Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/655157"},{"key":"e_1_2_6_3_1","first-page":"263","article-title":"Seroepidemiological study of hepatitis E virus in drug addicts in Ahvaz, Southern Iran: 2005\u20132006","volume":"8","author":"Alavi S. 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