{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:03:51Z","timestamp":1778900631149,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T00:00:00Z","timestamp":1487548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zoonoses and Public Health"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In order to estimate the prevalence of AmpC\u2010 and <jats:styled-content style=\"fixed-case\">ESBL<\/jats:styled-content> \u03b2\u2010lactamase\u2010producing <jats:italic>Enterobacteriaceae<\/jats:italic> in the faecal flora of a healthy domestic canine population, faecal samples were obtained from healthy dogs receiving routine parasitology screening at the Ohio State University Veterinary Medical Center, between January 2013 and April 2013. Samples were screened for the presence of AmpC and <jats:styled-content style=\"fixed-case\">ESBL<\/jats:styled-content> \u03b2\u2010lactamase phenotypes, and the clinically important genotypes, <jats:italic>bla<\/jats:italic><jats:styled-content style=\"fixed-case\"><jats:sub>CMY<\/jats:sub><\/jats:styled-content> and <jats:italic>bla<\/jats:italic><jats:styled-content style=\"fixed-case\"><jats:sub>CTX<\/jats:sub><\/jats:styled-content><jats:sub>\u2010M<\/jats:sub>, were confirmed via conventional <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>. Minimum inhibitory concentrations were determined for isolates and plasmids were characterized. Two hundred and twelve canine faecal samples were screened, of which 30 harboured isolates carrying the AmpC <jats:italic>bla<\/jats:italic><jats:styled-content style=\"fixed-case\"><jats:sub>CMY<\/jats:sub><\/jats:styled-content>, representing 14.2% of the population (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 9.4\u201318.9%). Nine samples harboured isolates that carried the <jats:styled-content style=\"fixed-case\">ESBL <\/jats:styled-content><jats:italic>bla<\/jats:italic><jats:styled-content style=\"fixed-case\"><jats:sub>CTX<\/jats:sub><\/jats:styled-content><jats:sub>\u2010M<\/jats:sub>, representing 4.2% of the population (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.5\u20137.0%). Isolates containing <jats:italic>bla<\/jats:italic><jats:styled-content style=\"fixed-case\"><jats:sub>CMY<\/jats:sub><\/jats:styled-content> harboured multiple plasmid replicon types, while isolates containing <jats:italic>bla<\/jats:italic><jats:styled-content style=\"fixed-case\"><jats:sub>CTX<\/jats:sub><\/jats:styled-content><jats:sub>\u2010M<\/jats:sub> harboured few plasmid replicon types. Our results suggest that domestic dogs may serve as a reservoir for extended\u2010spectrum cephalosporin resistance genes for other domestic animal populations as well as for their human companions. This represents a potential veterinary and public health risk that warrants further investigation and continued surveillance to ascertain the nature and extent of the risk. The high level of diversity of plasmid content among isolates harbouring <jats:italic>bla<\/jats:italic><jats:styled-content style=\"fixed-case\"><jats:sub>CMY<\/jats:sub><\/jats:styled-content> suggests broader dissemination relative to <jats:italic>bla<\/jats:italic><jats:styled-content style=\"fixed-case\"><jats:sub>CTX<\/jats:sub><\/jats:styled-content><jats:sub>\u2010M<\/jats:sub> isolates.<\/jats:p>","DOI":"10.1111\/zph.12341","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T17:10:06Z","timestamp":1487697006000},"page":"554-560","source":"Crossref","is-referenced-by-count":4,"title":["Prevalence of AmpC\u2010 and Extended\u2010Spectrum \u03b2\u2010Lactamase\u2010Harbouring <i>Enterobacteriaceae<\/i> in Faecal Flora of a Healthy Domestic Canine Population"],"prefix":"10.1111","volume":"64","author":[{"given":"D. A.","family":"Mathys","sequence":"first","affiliation":[{"name":"Department of Veterinary Preventive Medicine College of Veterinary Medicine The Ohio State University Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. F.","family":"Mollenkopf","sequence":"additional","affiliation":[{"name":"Department of Veterinary Preventive Medicine College of Veterinary Medicine The Ohio State University Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. A.","family":"Bremer","sequence":"additional","affiliation":[{"name":"Department of Veterinary Preventive Medicine College of Veterinary Medicine The Ohio State University Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. B.","family":"Daniels","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine The Ohio State University Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. E.","family":"Wittum","sequence":"additional","affiliation":[{"name":"Department of Veterinary Preventive Medicine College of Veterinary Medicine The Ohio State University Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,20]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"The Merck Veterinary Manual","author":"Boothe D. 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