{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:57:25Z","timestamp":1760122645374,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T00:00:00Z","timestamp":1490140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Yale College research fellowships"},{"name":"CJM. UW Center for One Health Research pilot funding; PMR."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zoonoses and Public Health"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Patients receiving immunosuppressive cancer treatments in settings where there is a high degree of human\u2013animal interaction may be at increased risk for opportunistic zoonotic infections or reactivation of latent infections. We sought to determine the seroprevalence of selected zoonotic pathogens among patients diagnosed with haematologic malignancies and undergoing chemotherapeutic treatments in Romania, where much of the general population lives and\/or works in contact with livestock. A convenience sample of 51 patients with haematologic cancer undergoing chemotherapy at a referral clinic in Cluj\u2010Napoca, Romania, was surveyed regarding animal exposures. Blood samples were obtained and tested for evidence of infection with <jats:italic>Bartonella<\/jats:italic> species, <jats:italic>Coxiella burnetii<\/jats:italic> and <jats:italic>Toxoplasma gondii<\/jats:italic>, which are important opportunistic zoonotic agents in immunocompromised individuals. 58.8% of participants reported living or working on a farm, and living or working on a farm was associated with contact with livestock and other animals. 37.5% of participants were IgG seroreactive against one or more of five <jats:italic>Bartonella<\/jats:italic> antigens, and seroreactivity was statistically associated with living on farms. Farm dwellers were 3.6 times more likely to test IgG seroreactive to <jats:italic>Bartonella<\/jats:italic> antibodies than non\u2010farm dwellers. 47.1% of the participants tested <jats:italic>T.\u00a0gondii<\/jats:italic> IgG positive and 13.7% tested <jats:italic>C.\u00a0burnetii<\/jats:italic> IgG positive, indicating past or latent infection. <jats:italic>C.\u00a0burnetii<\/jats:italic> IgM antibodies were detected in four participants (7.8%), indicating possible recent infection. These results indicate that a large proportion of patients with haematologic cancer in Romania may be at risk for zoonotic infections or for reactivation of latent zoonotic infections, particularly with respect to <jats:italic>Bartonella<\/jats:italic> species. Special attention should be paid to cancer patients' exposure to livestock and companion animals in areas where much of the population lives in rural settings.<\/jats:p>","DOI":"10.1111\/zph.12353","type":"journal-article","created":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T07:27:35Z","timestamp":1490254055000},"page":"485-490","source":"Crossref","is-referenced-by-count":8,"title":["Seroprevalence of <i>Bartonella<\/i> species, <i>Coxiella burnetii<\/i> and <i>Toxoplasma gondii<\/i> among patients with hematological malignancies: A pilot study in Romania"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0992-2111","authenticated-orcid":false,"given":"C. J.","family":"Messinger","sequence":"first","affiliation":[{"name":"Yale University  New Haven CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. S.","family":"Gurzau","sequence":"additional","affiliation":[{"name":"Environmental Health Center  Cluj\u2010Napoca Romania"},{"name":"Iuliu Hatieganu University of Medicine and Pharmacy  Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. B.","family":"Breitschwerdt","sequence":"additional","affiliation":[{"name":"Intracellular Pathogens Research Laboratory Center for Comparative Medicine and Translational Research College of Veterinary Medicine North Carolina State University  Raleigh NC USA"},{"name":"Galaxy Diagnostics, Research Triangle Park  NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. I.","family":"Tomuleasa","sequence":"additional","affiliation":[{"name":"Research Center for Functional Genomics Biomedicine and Translational Medicine Iuliu Hatieganu University of Medicine and Pharmacy  Cluj\u2010Napoca Romania"},{"name":"Department of Hematology Oncology Institute Ion Chiricuta  Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"Trufan","sequence":"additional","affiliation":[{"name":"Center for One Health Research Department of Environmental and Occupational Health Sciences University of Washington  Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. M.","family":"Flonta","sequence":"additional","affiliation":[{"name":"Microbiology Laboratory Infectious Diseases Hospital  Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. G.","family":"Maggi","sequence":"additional","affiliation":[{"name":"Intracellular Pathogens Research Laboratory Center for Comparative Medicine and Translational Research College of Veterinary Medicine North Carolina State University  Raleigh NC USA"},{"name":"Galaxy Diagnostics, Research Triangle Park  NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Berindan\u2010Neagoe","sequence":"additional","affiliation":[{"name":"Research Center for Functional Genomics Biomedicine and Translational Medicine Iuliu Hatieganu University of Medicine and Pharmacy  Cluj\u2010Napoca Romania"},{"name":"Department of Experimental Pathology Oncology Institute Ion Chiricuta  Cluj\u2010Napoca Romania"},{"name":"Department of Experimental Therapeutics M.D. Anderson Cancer Center University of Texas  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. M.","family":"Rabinowitz","sequence":"additional","affiliation":[{"name":"Center for One Health Research Department of Environmental and Occupational Health Sciences University of Washington  Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2014.04.006"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1051\/vetres:2005009"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv273"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ilar\/ilu015"},{"key":"e_1_2_8_6_1","first-page":"37","article-title":"Seroprevalence of anti Toxoplasma gondii antibodies in the healthy population from north\u2010western and central Romania","volume":"1","author":"Coroiu Z.","year":"2009","journal-title":"Scientia Parasitologica"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms12129504"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1863-2378.2009.01274.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182013001509"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61152-X"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-1897"},{"key":"e_1_2_8_12_1","first-page":"1","article-title":"Q fever in humans and farm animals in four European countries, 1982 to 2010","volume":"18","author":"Georgiev M.","year":"2013","journal-title":"Eurosurveillance Weekly"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2010.10.007"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2013.1512"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2011.09.001"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2009.07.002"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/pis085"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/612809"},{"key":"e_1_2_8_19_1","first-page":"1","article-title":"Seroprevalence of Bartonella henselae in patients awaiting heart transplant in Southern Italy","author":"Picascia A.","year":"2015","journal-title":"Journal of Microbiology, Immunology, and Infection"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/248418"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1990.tb42204.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/14.1.127"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(00)00134-X"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2011.0681"},{"key":"e_1_2_8_25_1","first-page":"391","article-title":"Investigation of Bartonella henselae seroprevalence and related risk factors in blood donors admitted to Pamukkale University Blood Center","volume":"43","author":"Yilmaz C.","year":"2009","journal-title":"Mikrobiyoloji Bulteni"}],"container-title":["Zoonoses and Public Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fzph.12353","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/zph.12353","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T21:31:27Z","timestamp":1696023087000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/zph.12353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,22]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/zph.12353"],"URL":"https:\/\/doi.org\/10.1111\/zph.12353","archive":["Portico"],"relation":{},"ISSN":["1863-1959","1863-2378"],"issn-type":[{"type":"print","value":"1863-1959"},{"type":"electronic","value":"1863-2378"}],"subject":[],"published":{"date-parts":[[2017,3,22]]}}}