{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:45:33Z","timestamp":1761896733146,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,4]],"date-time":"2018-02-04T00:00:00Z","timestamp":1517702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zoonoses and Public Health"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A randomized controlled trial (<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>) was carried to evaluate the effect of a feed additive on <jats:italic>Campylobacter<\/jats:italic> contamination of broilers reared in commercial conditions. Twenty\u2010four broiler flocks naturally contaminated with <jats:italic>Campylobacter<\/jats:italic> were enrolled in the <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>: 12 were assigned to a control group (C) fed with a conventional finishing feed from 4\u00a0weeks of age to slaughter (around 35\u00a0days), and the other group of 12 flocks (S) was fed with a finishing feed supplemented with 250\u00a0ppm of a patented feed additive (an ion\u2010exchanged clay compound) previously proven to reduce <jats:italic>Campylobacter<\/jats:italic> contamination in broiler caeca under experimental conditions. Enumeration of <jats:italic>Campylobacter<\/jats:italic> colonies in caeca (8 per flock) was carried out following <jats:styled-content style=\"fixed-case\">ISO<\/jats:styled-content> standards before feed distribution and at slaughter. Before treatment, the caecal <jats:italic>Campylobacter<\/jats:italic> load tended to be lower in C flocks (7.1\u00a0\u00b1\u00a01.9 log <jats:styled-content style=\"fixed-case\">CFU<\/jats:styled-content>\/g, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content><jats:sub>95%<\/jats:sub> [6.6\u20137.5]) than in S flocks (7.7\u00a0\u00b1\u00a01.0 log <jats:styled-content style=\"fixed-case\">UFC<\/jats:styled-content>\/g, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content><jats:sub>95%<\/jats:sub> [7.5\u20137.9]) (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.05). At slaughter, the bacterial load was similar in the S (7.7\u00a0\u00b1\u00a01.0 log <jats:styled-content style=\"fixed-case\">CFU<\/jats:styled-content>\/g, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content><jats:sub>95%<\/jats:sub> [7.5\u20137.9]) and C groups (7.5\u00a0\u00b1\u00a01.2 log <jats:styled-content style=\"fixed-case\">CFU<\/jats:styled-content>\/g, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content><jats:sub>95%<\/jats:sub> [7.2\u20137.8]) (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.73). Therefore, the feed additive had no significant effect on the caecal <jats:italic>Campylobacter<\/jats:italic> load at slaughter under the tested conditions. The logistical constraints inherent in field trials and the natural variability of <jats:italic>Campylobacter<\/jats:italic> contamination in naturally infected broiler flocks make it difficult to reproduce experimental results in in situ farm conditions. <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content> testing of an intervention strategy in commercial situation is therefore a key step in evaluating pre\u2010harvest interventions against food\u2010borne pathogens.<\/jats:p>","DOI":"10.1111\/zph.12447","type":"journal-article","created":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T04:06:40Z","timestamp":1517803600000},"page":"404-411","source":"Crossref","is-referenced-by-count":7,"title":["Randomized control trial to test the effect of a feed additive on <i>Campylobacter<\/i> contamination in commercial broiler flocks up to slaughter"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2343-5176","authenticated-orcid":false,"given":"A.","family":"Huneau\u2010Sala\u00fcn","sequence":"first","affiliation":[{"name":"ANSES \u2013 Ploufragan\u2010Plouzan\u00e9 Laboratory  Ploufragan France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Guyard\u2010Nicod\u00e8me","sequence":"additional","affiliation":[{"name":"ANSES \u2013 Ploufragan\u2010Plouzan\u00e9 Laboratory  Ploufragan France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Benzoni","sequence":"additional","affiliation":[{"name":"SA INVIVO NSA, Talhou\u00ebt  Saint Nolff France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Gautier","sequence":"additional","affiliation":[{"name":"Huttepain Aliment Groupe LDC  La Chapelle St Aubin France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Quesne","sequence":"additional","affiliation":[{"name":"ANSES \u2013 Ploufragan\u2010Plouzan\u00e9 Laboratory  Ploufragan France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Po\u00ebzevara","sequence":"additional","affiliation":[{"name":"ANSES \u2013 Ploufragan\u2010Plouzan\u00e9 Laboratory  Ploufragan France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Chemaly","sequence":"additional","affiliation":[{"name":"ANSES \u2013 Ploufragan\u2010Plouzan\u00e9 Laboratory  Ploufragan France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,4]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1080\/00071668.2014.941788"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.3382\/ps.2008-00010"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.2903\/j.efsa.2011.2105"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.2903\/j.efsa.2014.3547"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.3382\/ps\/pev346"},{"unstructured":"Guyard\u2010Nicod\u00e8me M. 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