{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:19:47Z","timestamp":1790029187175,"version":"4.0.1"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T00:00:00Z","timestamp":1518393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zoonoses and Public Health"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The canine variant of the rabies virus has been eliminated in the United States. Among the public and many healthcare providers, however, dog bites are still associated with risk for rabies transmission. This study examined the risk of rabies in biting dogs and the use of rabies post\u2010exposure prophylaxis (<jats:styled-content style=\"fixed-case\">rPEP<\/jats:styled-content>) for dog bite victims in Tennessee. The study included a retrospective analysis of laboratory testing requisitions for dogs from 2002 to 2016, collection of clinical data on confirmed rabies\u2010positive dogs from 2008 to 2016 and analysis of hospital discharge data for<jats:styled-content style=\"fixed-case\">rPEP<\/jats:styled-content>from 2007 to 2014. Among dogs submitted for rabies testing, those having a recent history of biting were significantly less likely to test positive for rabies than dogs with no reported bite (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.01; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>[0.003\u20130.04]). The most common clinical signs reported among rabies\u2010positive dogs were anorexia, dysphagia, ataxia, limb paresis or paralysis, and lethargy; aggressiveness was uncommon. Among hospital patients with an animal\u2010related injury who received<jats:styled-content style=\"fixed-case\">rPEP<\/jats:styled-content>, more than half (52%) presented with dog bites. These data show that laboratory submissions for rabies testing and prescriptions for<jats:styled-content style=\"fixed-case\">rPEP<\/jats:styled-content>do not reflect the epidemiology of rabies in Tennessee. Education and outreach targeting the public and healthcare providers should emphasize the animal species and situations associated with a greater risk for rabies transmission, such as bites from rabies reservoir species or animals exhibiting signs of neurologic disease.<\/jats:p>","DOI":"10.1111\/zph.12451","type":"journal-article","created":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T06:34:41Z","timestamp":1518417281000},"page":"425-430","source":"Crossref","is-referenced-by-count":4,"title":["Rabies risk and use of post\u2010exposure prophylaxis associated with dog bites in Tennessee"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2197-3149","authenticated-orcid":false,"given":"H.","family":"Henderson","sequence":"first","affiliation":[{"name":"Tennessee Department of Health Division of Communicable and Environmental Diseases and Emergency Preparedness Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. R.","family":"Carpenter","sequence":"additional","affiliation":[{"name":"Tennessee Department of Health Division of Communicable and Environmental Diseases and Emergency Preparedness Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. R.","family":"Dunn","sequence":"additional","affiliation":[{"name":"Tennessee Department of Health Division of Communicable and Environmental Diseases and Emergency Preparedness Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.248.5.505"},{"issue":"3","key":"e_1_2_7_3_1","first-page":"1","article-title":"Human rabies prevention\u2014United States, 2008: Recommendations of the Advisory Committee on Immunization Practices","volume":"57","author":"Centers for Disease Control and Prevention (CDC)","year":"2008","journal-title":"MMWR Recommendations and Reports"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.245.10.1111"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2460\/javma.1990.197.02.201","article-title":"Epidemiologic factors, clinical findings, and vaccination status of rabies in cats and dogs in the United States in 1988. National Study Group on Rabies","volume":"197","author":"Eng T. 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