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Although a licensed vaccine to prevent infection by the\n                    <jats:styled-content style=\"fixed-case\">CCHF<\/jats:styled-content>\n                    virus (\n                    <jats:styled-content style=\"fixed-case\">CCHFV<\/jats:styled-content>\n                    ) exists, its ability to induce neutralizing antibodies is limited and its efficacy against\n                    <jats:styled-content style=\"fixed-case\">CCHFV<\/jats:styled-content>\n                    remains undetermined. In addition, controlling\n                    <jats:styled-content style=\"fixed-case\">CCHF<\/jats:styled-content>\n                    infections by eradication of the tick reservoir has been ineffective, both economically and logistically, and the treatment options for\n                    <jats:styled-content style=\"fixed-case\">CCHF<\/jats:styled-content>\n                    remain limited. In this review, we first critically discuss the existing animal models to evaluate therapeutics for\n                    <jats:styled-content style=\"fixed-case\">CCHF<\/jats:styled-content>\n                    . We then review the therapeutic options for\n                    <jats:styled-content style=\"fixed-case\">CCHF<\/jats:styled-content>\n                    that have been investigated in human cases, followed by investigational drugs that have been evaluated in pre\u2010clinical studies. We highlight the importance of understanding human prognostic factors in developing an animal model for\n                    <jats:styled-content style=\"fixed-case\">CCHF<\/jats:styled-content>\n                    that recapitulates hallmarks of human disease and its implication for selecting therapeutic candidates.\n                  <\/jats:p>","DOI":"10.1111\/zph.12469","type":"journal-article","created":{"date-parts":[[2018,4,20]],"date-time":"2018-04-20T06:41:18Z","timestamp":1524206478000},"page":"465-480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Crimean\u2013Congo haemorrhagic fever virus: Past, present and future insights for animal modelling and medical countermeasures"],"prefix":"10.1111","volume":"65","author":[{"given":"E. 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